Results 91 to 100 of about 308,174 (247)

Engineering Antigen Density on M13 Bacteriophage for Personalized Nanovaccine

Advanced Healthcare Materials, EarlyView.
Increasing antigen density on the phage capsid impacts phage uptake and antigen cross‐presentation by antigen‐presenting cells, leading to enhanced activation of antitumor CD8+ T cells in the draining lymph nodes. These activated CD8+ T cells subsequently recognize the antigen‐expressing tumors and mediate their specific cytotoxic killing, thereby ...
Shengnan Huang, Allison Madow, Jack Rudrum, Huaiyao Peng, Hao Nghi Luu, Peiyan Dong, Jifa Qi, Angela M. Belcher   +7 more
wiley   +1 more source

Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency

Advanced Materials, EarlyView.
As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang, Jerry Leung, Judy Cheng, Arash Momeni, Albert Kamanzi, Ariadne Tuckmantel Bido, Suiyang Liao, Emma Kang, Colton Strong, Christian J. Kastrup, Sabrina Leslie, Miffy Hok Yan Cheng, Pieter R. Cullis   +12 more
wiley   +1 more source

Preclinical immunogenicity of the LP.8.1-adapted BNT162b2 COVID-19 vaccine

npj Vaccines
SARS-CoV-2 evolution toward antigenically distinct lineages drives escape from host immunity. JN.1 lineage derivatives have recently dominated the global epidemiologic landscape.
Chaitanya Kurhade, Wei Chen, Weiqiang Li, Kristin R. Tompkins, Lyndsey T. Martinez, Swati Rajput, Emily Babiarz, Aaron Yam, Shin-Ae Lee, Shikha Shrivastava, Sarah O’Leary, Subrata Saha, Hui Yao, Li Hao, Todd Coffey, Carla Iris Cadima Couto, Alexander Muik, Raquel Munoz Moreno, Wesley Swanson, Pilar Mendoza, Uğur Şahin, Annaliesa S. Anderson, Kena A. Swanson, Pirada Suphaphiphat Allen, Kayvon Modjarrad   +24 more
doaj   +1 more source

Charge‐Reversed Lipid Nanoparticles Enable Encapsulation of Pt2L4 Nanocages for In vivo Anti‐Cancer Treatment

Advanced Materials, EarlyView.
Charge‐reversed lipid nanoparticles (revLNPs) enable efficient encapsulation and delivery of cationic Pt2L4 nanocages. Encapsulation preserves potent anticancer activity while improving circulation, reducing vascular leakage, and promoting favorable biodistribution in vivo.
Renzo A. Knol, Bochuan Hu, Eduard O. Bobylev, Martina Farber, Petrus C. M. Laan, Thomas J. F. Kock, Bauke Fontein, Johanna Erbani, Oscar Escalona‐Rayo, Seline S. Roose, Tom Keijer, Gabriel Forn‐Cuní, B. Ewa Snaar‐Jagalska, Leila Akkari, Joost N. H. Reek, Alexander Kros, Dennis Aschmann   +16 more
wiley   +1 more source

Acknowledgement to Reviewers of Vaccines in 2019

Vaccines, 2020
Vaccines Editorial Office
doaj   +1 more source

Bivalent RSV prefusion F vaccination elicits effective neutralization of contemporary and monoclonal antibody-resistant RSV strains

npj Vaccines
Respiratory syncytial virus (RSV) is the leading global cause of serious respiratory disease in infants and an important respiratory pathogen in older adults.
Wei Chen, Lyndsey T. Martinez, Larissa Falcao, Zhenghui Li, Andrew P. McKeen, Chaitanya Kurhade, Hélène Boigard, Vidia Roopchand, Imani Richardson, Trisha Dasgupta, Katrina E. Llamera, Jing Colatat, Linda Goding Brock, Annaliesa S. Anderson, Kena A. Swanson   +14 more
doaj   +1 more source

Biomass DNA: An Emerging Building Block for Advanced Materials

Advanced Materials, EarlyView.
Biomass DNA is rapidly emerging from its traditional role as a genetic blueprint to serve as a versatile abundant, highly programmable polymeric building block. This review highlights the transformation of macroscopic bulk biomass DNA into next generation of functional materials, spanning from dynamic hydrogels, sustainable bioplastics, and high ...
Yuwei Hu, Itamar Willner, Li Niu
wiley   +1 more source

Boosting neuraminidase immunity in the presence of hemagglutinin with the next generation of influenza vaccines

npj Vaccines
Neuraminidase (NA), the second most abundant surface glycoprotein on the influenza virus, plays a key role in viral replication and propagation. Despite growing evidence showing that NA-specific antibodies correlate with resistance to disease in humans ...
Guadalupe Cortés, Irina Ustyugova, Timothy Farrell, Clint McDaniel, Colleen Britain, Christopher Romano, Siré N’Diaye, Lingyi Zheng, Mithila Ferdous, Justin Iampietro, Svetlana Pougatcheva, Lauren La Rue, Liqun Han, Fuqin Ma, Svetlana Stegalkina, Satyajit Ray, Jianxin Zhang, Mario Barro   +17 more
doaj   +1 more source

Vaccines, Vaccines, Vaccines [PDF]

The Biochemist, 2021
openaire   +1 more source

Epitope-based vaccines for cancer

, 2011
INTRODUCTION Epitope-based cancer vaccination, comprised of minimal immunogenic portions of a cancer antigen, represents an immunotherapy that combines target specifi city with long-lasting immunity. Advances in epitope identifi cation and immunogenicity

core   +1 more source