Results 161 to 170 of about 806,967 (237)

Immunostimulatory DNA Tetrahedron‐Based Nanovaccine Combined With Immune Checkpoint PD‐1 Blockade for Boosting Systemic Immune Responses Against Oral Squamous Cell Carcinoma

Aggregate, EarlyView.
This study introduces an immunomodulatory DNA tetrahedral framework nucleic acid‐based nanovaccine tFNA‐CpG. The functionalized nanovaccine shows stable and well‐defined morphological characteristics and can be efficiently taken up by APCs. When combined with the immune checkpoint inhibitor anti‐PD‐1, it notably ameliorated the immunosuppressive ...
Xueting Yang, Yun Wang, Yan Yang, Sicheng Zhang, Dianri Wang, Yi Luo, Chunyan Shui, Yongcong Cai, Ruoyi Yang, Shuang Dong, Mu Yang, Yunfeng Lin, Chao Li   +12 more
wiley   +1 more source

Vaccine Hesitancy Through a Global Lens: Cross-Cultural Evidence from a Special Issue. [PDF]

Vaccines (Basel)
Shah GH, Nguyen TH.
europepmc   +1 more source

Diglycerides of Natural Phenols and Organic Acids for Enhanced Biological Activities

Asian Journal of Organic Chemistry, EarlyView.
Diglycerides of natural organic acids and phenols were synthesized regio‐selectively. Diglycerides are structurally similar to cell membranes and are expected to exhibit cell affinity and permeability. The flexible glycerol linkers allow the diglycerides to exhibit not only the physiological activities of each constituent organic acid but also the ...
Jisu Hong, Seunghyo Han, Huisu Yeo, Chanyoung Boo, Hyein Kim, Eunbi Kim, Boram Lim, Yeon Jeong Jo, Ji‐Seon Hyun, Nam Ho Lee, Sangho Koo   +10 more
wiley   +1 more source

rLVS Δ<i>capB</i>/Yp F1-V single vector platform vaccine expressing <i>Yersinia pestis</i> F1 and LcrV antigens provides complete protection against lethal respiratory challenge with virulent plague bacilli. [PDF]

Hum Vaccin Immunother
Jia Q, Bowen RA, Masleša-Galić S, Horwitz MA.   +3 more
europepmc   +1 more source

Respiratory virus mRNA vaccines: mRNA Design, clinical studies, and future challenges

Animal Models and Experimental Medicine, EarlyView.
Abstract Respiratory infectious diseases frequently erupt on a global scale, with RNA viruses, such as SARS‐CoV‐2, RSV, and influenza viruses, posing challenges to vaccine development due to their high mutation rates. Traditional vaccine development cycles are lengthy and struggle to keep pace with rapidly evolving viruses, whereas messenger RNA (mRNA)
Linlin Zheng, Han Feng
wiley   +1 more source

Development of bivalent RBD adapted COVID-19 vaccines for broad sarbecovirus immunity. [PDF]

NPJ Vaccines
Bruno LA, Pueblas Castro C, Demaría A, Prado L, Fascetto Cassero CG, Saposnik LM, Páez Córdoba F, Rodriguez JM, Piccini G, Antonelli R, Lapini G, Temperton N, Del Priore SA, Hernando Insua AC, Kaufmann IG, Vega JC, Flo JM, Pasquevich KA, Coria LM, Cassataro J.   +19 more
europepmc   +1 more source

Vaccines and vaccination strategies

Expert Review of Vaccines, 2004
openaire   +3 more sources

Biocompatibility and healing patterns in experimentally induced canine tibial fractures using Pedicle screw‐Rod external fixation

Animal Models and Experimental Medicine, EarlyView.
This study demonstrates that using a Pedicle screw‐Rod configuration for the external fixation of non‐articular tibial osteotomy aligns well with the principles of biological osteosynthesis, resulting in secondary bone healing characterized by callus formation and neovascularization.
Mohammad Mahdi Gooran, Ramin Mazaheri‐Khameneh, Seyed Mohammad Hashemi‐Asl, Rahim Hobbenaghi   +3 more
wiley   +1 more source

Mapping the role of vaccines in combating AMR in the WHO African region: a scoping review and implications for research and policy. [PDF]

BMC Infect Dis
Iwu-Jaja C, Gahimbare L, Mazingisa AV, Fuller W, Mazengiya DY, Okeibunor J, Olu OO, Katoto PMC, Yahaya AA, Nyarko K, Wiysonge CS.   +10 more
europepmc   +1 more source

Comparative pathogenicity of vaccinia virus and mpox virus infections in CAST/EiJ mice: Exploring splenomegaly and transcriptomic profiles

Animal Models and Experimental Medicine, EarlyView.
We successfully constructed CAST/EiJ mice models infected with low‐dose vaccinia virus (VACV‐L), high‐dose VACV (VACV‐H), and mpox virus (MPXV), demonstrating that VACV‐L and MPXV infections induced splenomegaly in mice, and VACV‐H infection caused mortality in mice.
Yongzhi Hou, Jianrong Ma, Baoying Huang, Na Li, Lin Zhu, Ziqing Jia, Jiasen Yang, Jingjing Zhang, Wenjie Tan, Jing Xue   +9 more
wiley   +1 more source