Results 281 to 290 of about 1,229,162 (345)
Etiologies and comorbidities of meningitis deaths in children under 5 years in high-mortality settings: Insights from the CHAMPS Network in the post-pneumococcal vaccine era [PDF]
Sana Mahtab, Zachary J. Madewell, Vicky L. Baillie, Ziyaad Dangor, Sanjay G. Lala, Nega Assefa, Mulu Berihun, Lola Madrid, Lemma Demissie Regassa, J. Anthony G. Scott, Soter Ameh, Joseph Bangura, Okokon Ita, Erick Kaluma, Ikechukwu U. Ogbuanu, Brigitte Gaume, Karen L. Kotloff, Samba O. Sow, Milagritos D. Tapia, Sara Ajanovic, Marcelino Garrine, Inácio Mandomando, Rosauro Varo, Elísio Xerinda, Muntasir Alam, Shams El Arifeen, Emily S. Gurley, Mohammad Zahid Hossain, Mahbubur Rahman, Victor Akelo, Kitiezo Aggrey Igunza, Clayton Onyango, Dickens Onyango, Jennifer R. Verani, Portia Mutevedzi, Cynthia G. Whitney, Dianna M. Blau, Shabir A. Madhi, Quique Bassat +38 moreopenalex +1 more sourceTargeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity
Advanced Science, EarlyView.Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.Nicolas Marzolini, Taylor V. Brysgel, Ryan J. Rahman, Eno‐Obong Essien, Saw Y. Nwe, Jichuan Wu, Aparajeeta Majumder, Manthan N. Patel, Sachchidanand Tiwari, Carolann L. Espy, Fengyi Dong, Sabrina A. Santos‐De León, Anit Shah, Vladimir V. Shuvaev, Elizabeth D. Hood, Liam S. Chase, Drew Weissman, Jeremy B. Katzen, David B. Frank, Mariko L. Bennett, Oscar A. Marcos‐Contreras, Jacob W. Myerson, Vladimir R. Muzykantov, Sahily Reyes‐Esteves, Jacob S. Brenner +24 morewiley +1 more sourceCOVID-19 Vaccination Knowledge, Attitudes, Perception, and Practices Among Frontline Healthcare Workers in Tunisia, 2024. [PDF]
Vaccines (Basel)Ben Youssef F, Hechaichi A, Letaief H, Dhaouadi S, Zouaiti A, Talmoudi K, Fitouri S, Fourati A, Mhadhbi R, Sahli A, Nahdi G, Nouira K, Basha I, Bazant E, Griffin C, Palmer K, Alaya NBEB. +16 moreeuropepmc +1 more sourceProtein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV
Cara W. Chao, Kaitlin R. Sprouse, Marcos C. Miranda, Nicholas Catanzaro, Miranda L. Hubbard, Amin Addetia, Cameron Stewart, Jack T Brown, Annie Dosey, Adian Valdez, Rashmi Ravichandran, Grace G. Hendricks, Maggie Ahlrichs, Craig L. Dobbins, Alexis Hand, Jackson McGowan, Blake A. Simmons, Catherine Treichel, Isabelle Willoughby, Alexandra C. Walls, Andrew T. McGuire, Elizabeth M. Leaf, Ralph S. Baric, Alexandra Schäfer, David Veesler, Neil P. King +25 moreopenalex +1 more sourceAIEgen‐Based Proactive Early Warning System and Precise Treatment Strategy for Monkeypox Prevention and Control
Advanced Science, EarlyView.An intelligent early warning and treatment system for monkeypox, utilizing a sprayable AIEgen‐ liquid dressing (AIE@LD) that responds to lesion pH. Integrated with a smartphone app and cloud platform, it enables real‐time infection detection via fluorescence imaging and triggers on‐demand photodynamic therapy under white light, effectively eradicating ...Wei Wang, Zining Liu, Mengjun Li, Judun Zheng, Ruilin Zhang, Ke Liu, Xiaoxue Li, Shaoying Wen, Jingze Yu, Meijia Pan, Fengbo Ma, Kun Zhou, Zheng Zhao, Chenguang Shen, Yuhui Liao +14 morewiley +1 more sourceMucin‐Inspired Filamentous Sulfated Copolymers Effectively Inhibit Human Respiratory Syncytial Virus (hRSV) Infectivity
Advanced Science, EarlyView.Virucidal polymers serve as effective antivirals by not only inhibiting viruses but also destroying them. Inspired by the chemical properties of mucin‐mimetics, dendronized polyglycerol‐sulfated, mucin‐inspired amphiphilic copolymers (MIACPs) have been developed.Raju Bej, Enyu Xie, Kai Ludwig, Robert F. Schmidt, Yannic Kerkhoff, Robert Dalgliesh, Nilanjan Paul, Michael Gradzielski, Andreas Herrmann, Christian Sieben, Rainer Haag +10 morewiley +1 more sourceAlkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma
Advanced Science, EarlyView.This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT
In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...Kaiyuan Liu, Ruotong Li, Li Zhang, Hengli Lu, Binhui Yang, Qian Hu, Yining Tao, Haoran Mu, Jing Han, Pengfei Zan, Jiakang Shen, Dongqing Zuo, Hongsheng Wang, Wei Sun, Xingjun Zhu +14 morewiley +1 more source