Results 281 to 290 of about 1,792,624 (390)

Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

Nature Microbiology, 2020
W. Lee, A. Wheatley, S. Kent, B. Dekosky
semanticscholar   +1 more source

An Aptamer‐Based EXACT Anticoagulant as a Sustainable, Animal‐Free Alternative to Unfractionated Heparin

Advanced Science, EarlyView.
By simply conjugating thrombin's active‐site inhibitor, dabigatran, with an exosite inhibitor, aptamer HD1, the resulting EXosite‐ACTive site (EXACT) inhibitors show two orders of magnitude higher potency and selectivity via synergistic binding, while maintaining the aptamer's antidote‐reversible trait, yielding a potential substitute for the animal ...
Haixiang Yu, George Pitoc, Manqi Zhang, Jeffrey Clancy, James Frederiksen, Amy Yan, Samuel Francis, Rebecca Sullenger, Rachel Rempel, Susannah Gammell, Jillian Caiazzi, Bruce A. Sullenger   +11 more
wiley   +1 more source

Yeast vaccine production platform for human and animal infectious diseases. [PDF]

Front Immunol
Ramos-Vega A, Monreal-Escalante E, Bañuelos-Hernández B, Angulo M, Trujillo E, Angulo C.   +5 more
europepmc   +1 more source

Safety and Efficacy of Adoptive Transfer of Stem Cell Memory Enriched Virus Specific T Cells against CMV and EBV

Advanced Science, EarlyView.
This study finds that CD8⁺ TSCM cells exhibit superior self‐renewal, differentiation, and antiviral activity. Transcriptome and epigenome analyses highlight MAPK cascade regulation in TSCM cells. In vivo, virus‐specific TSCM cells show enhanced persistence and tumor protection.
Xun‐Hong Cao, Xu‐Ying Pei, Yuan‐Yuan Zhang, Juan Xie, Jing‐Wei Tu, Zhuo‐Jun Liu, Yi‐Yang Ding, Chen‐Hua Yan, Yu‐Hong Chen, Yu Wang, Lan‐Ping Xu, Xiao‐Hui Zhang, Xiao‐Jun Huang, Xiang‐Yu Zhao   +13 more
wiley   +1 more source

mRNA Cancer Vaccines: From Pandemic Paradigm to Personalized Oncology Therapeutics. [PDF]

Cancer Innov
Yang B, Liu J, Li Y, Liu X.
europepmc   +1 more source

Size‐Dependent Ultrasound Activation of Thrombin Catalytic Activity by Mechano‐Nanoswitches

Advanced Science, EarlyView.
The fundamental principles linking nanoparticle (NP) physicochemical properties to their interactions with sonomechanical forces are not well‐defined. This work systematically investigates the size‐dependent ultrasound activation of thrombin using different‐sized mechano‐nanoswitches, which provides critical insights into the role of NP size in nano ...
Menghan Xiao, Zhihuan Liao, Junliang Chen, Xiong Zuo, Jiangting Zeng, Xiangfu Du, Zihao Teng, Johannes Hahmann, Andreas Herrmann, Shuaidong Huo   +9 more
wiley   +1 more source

Understanding the drivers and barriers of elderly vaccination in post-pandemic China: a qualitative study in Shenzhen. [PDF]

BMC Public Health
Deng Z, Huang F, Lee ROL, Grépin KA.
europepmc   +1 more source

Evaluation of reproductive protection against bovine viral diarrhea virus and bovine herpesvirus-1 afforded by annual revaccination with modified-live viral or combination modified-live/killed viral vaccines after primary vaccination with modified-live viral vaccine

, 2017
Paul H. Walz, M. Daniel Givens, Soren P. Rodning, K.P. Riddell, Bruce W. Brodersen, Daniel W. Scruggs, Timothy G. Short, Dale M. Grotelueschen   +7 more
openalex   +1 more source

Low-fidelity Venezuelan equine encephalitis virus polymerase mutants to improve live-attenuated vaccine safety and efficacy [PDF]

, 2018
Tiffany F. Kautz, Mathilde Guerbois, Kamil Khanipov, Edward I. Patterson, Rose M. Langsjoen, Ruimei Yun, Kelsey Lane Warmbrod, Yuriy Fofanov, Scott C. Weaver, Naomi L. Forrester   +9 more
openalex   +1 more source

Single‐Cell Insights Into Macrophage Subtypes in Pulmonary Infections

Advanced Science, EarlyView.
This review highlights the dynamic plasticity of macrophages during pulmonary infections and proposes an integrative framework defining six functional subtypes: Inflam‐Ms, Hub‐Ms, Reg‐Ms, Prolif‐Ms, Memory‐Ms, and Senesc‐Ms. Single‐cell omics delineate their distinct roles in homeostasis and infection, refining our understanding of macrophage ...
Zhaoheng Lin, Yuxiao Zheng, Yu Zhong, Hongyan Wang   +3 more
wiley   +1 more source