Results 311 to 320 of about 1,792,624 (390)

Comparison of safety and immunogenicity between Healive®, Havrix® and live attenuated Hepatitis A vaccines in pediatric population: a systematic review with meta-analysis. [PDF]

Ital J Pediatr
Abo Zeid M, Elrosasy A, Farho MA, Rifai M, Aboelkhier MM, Elkhrashy MN, Zabady AH, Zaki MSA, Hamed EM, Dawood SA, Abuzaid Y.   +10 more
europepmc   +1 more source

Vaccination [PDF]

Science, 1894
openaire   +2 more sources

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

mRNA-Based Neoantigen Vaccines in Pancreatic Ductal Adenocarcinoma (PDAC)-A Promising Avenue in Cancer Immunotherapy. [PDF]

Int J Mol Sci
Kabut J, Stopyra M, Nafalska N, Stępień GJ, Miciak M, Jezierzański M, Furgoł T, Feret K, Gisterek-Grocholska I.   +8 more
europepmc   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Current Status and Challenges of Vaccine Development for Seasonal Human Coronaviruses. [PDF]

Vaccines (Basel)
Zhang B, Liu Y, Chen T, Lai J, Liu S, Liu X, Zhu Y, Rao H, Peng H, Ma X.   +9 more
europepmc   +1 more source

Bimetallic Peroxide Nanocomposites‐Driven Redox Dyshomeostasis to Activate Sequential Cuproptosis and Pyroptosis for Amplified Tumor Immunotherapy

Advanced Science, EarlyView.
Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He, Haixia Zhu, Peipei Kang, Lili Feng, Chenghao Yu, Yanlin Zhu, Bin Liu, Zhengxiao Guo, Piaoping Yang   +8 more
wiley   +1 more source

The vaccination status and attitudes toward human papillomavirus among gynecologists in China: A cross-sectional survey. [PDF]

Hum Vaccin Immunother
Huang Y, He M, Li L, Xie R, Li D, Yang Z, Li Q, Guo M, Wang J, Hao H, Li X, Zheng Q, Long L, Zhou Q, Zou D.   +14 more
europepmc   +1 more source

A Rationally Engineered Spleen‐Tropic One‐Component Lipid‐mRNA Complex (OncoLRC) for Cancer Vaccines

Advanced Science, EarlyView.
OncoLRC, a one‐component lipid‐mRNA complex, enables efficient spleen‐targeted delivery at an exceptionally low lipid‐to‐mRNA mass ratio (1.5:1), robustly activates immune responses, inhibits tumor growth, and synergizes with checkpoint blockade, presenting a next‐generation platform for mRNA vaccines.
Qimeng Yin, Chenchen Zhang, Jiahao Li, Kun Huang, Min Qiu   +4 more
wiley   +1 more source

Comparative analysis of adenovirus, mRNA, and protein vaccines reveals context-dependent immunogenicity and efficacy. [PDF]

JCI Insight
Awakoaiye B, Li S, Sanchez S, Dangi T, Irani N, Arroyo L, Arellano G, Mohammadabadi S, Aid M, Penaloza-MacMaster P.   +9 more
europepmc   +1 more source