An Engineered Probiotic Consortium Based on Quorum‐Sensing for Colorectal Cancer Immunotherapy
Advanced Science, EarlyView.This work develops an engineered probiotic consortium sensing pH, hypoxia, and lactate in the tumor microenvironment. It releases a lactate‐depleting enzyme (LdhA) and a PD‐L1 nanobody. In humanized mouse models (MC38 and HT‐29 tumors), it achieves durable oscillations, suppresses tumors, activates CD8+, CD4+, IFN‐γ+ T cells, and reduces Foxp3 ...
Yufei Guo +11 more
wiley +1 more source
The efficacy and effectiveness of COVID-19 vaccines in Iran: a systematic review and meta-analysis. [PDF]
BMC Infect DisMousavi SM +3 more
europepmc +1 more source
Emerging Nanozyme Strategies for Precision Breast Cancer Treatment
Advanced Science, EarlyView.Different types of nanozymes‐mediated chemotherapy, photothermal therapy, immunotherapy, and multiple combined therapies for the effective treatment of breast cancer. Abstract Breast cancer, the most common malignant tumor among women worldwide, poses a significant challenge to public health due to its high incidence and mortality rates.
Jian Zang +6 more
wiley +1 more source
Advanced Science, EarlyView.The self‐trapped excitons in carbon quantum dots can serve as NIR‐II absorbers, which efficiently induce pyroptosis by driving the generation of reactive oxygen species through mild NIR‐II photothermal effect. Combined with local photophysical therapy and the cascade reaction of pyroptosis, it can activate systemic immunity and prevent tumor recurrence.
Tesen Zhang +10 more
wiley +1 more source
Hydrogel-Based Vaccines: A Promising Approach for Cancer Immunotherapy. [PDF]
Int J NanomedicineZhang W +6 more
europepmc +1 more source
Advanced Science, EarlyView.Precision targeting of the spleen and myeloid cells of the tumor microenvironment, with minimal hepatic delivery, is achieved using a modular peptide dendrimer‐lipid nanocarrier. Functional assays, transcriptomics, and rodent models validate this novel myeloid cell targeting nanocarrier as an efficacious immunotherapy, both as a cancer vaccine platform
Lawrence James Billing +9 more
wiley +1 more source
Publisher Correction: AI-driven epitope prediction: a systematic review, comparative analysis, and practical guide for vaccine development. [PDF]
NPJ VaccinesVillanueva-Flores F +2 more
europepmc +1 more source
Identifying Key Questions and Challenges in Microchimerism Biology
Advanced Science, EarlyView.This study identifies key unanswered questions about microchimerism, the presence of cells from one individual living in another. Experts highlight how these cells may affect health, pregnancy, and disease. This study outlines research priorities and challenges in detecting and studying these rare microchimeric cells, aiming to guide future discoveries
Kristine J. Chua +31 more
wiley +1 more source
Adverse effects and SARS-CoV-2 infection after COVID-19 vaccination among the vaccinated people of Bangabandhu Sheikh Mujib Medical University Hospital in Dhaka, Bangladesh: a pilot study. [PDF]
Sci RepSharmin E, Majumder K, Foyez Ahmed S.
europepmc +1 more source