Results 101 to 110 of about 225,485 (404)

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

Alteration of SH-group Contents in Red Beet Roots and Vacuoles under Osmotic Stress [PDF]

Journal of Stress Physiology & Biochemistry, 2013
The content of sulfhydryl groups in homogenate of red beets and isolated vacuoles under the conditions of osmotic stress was determined. It was demonstrated that the common content of sulfhydryl groups in the isolated vacuoles was 2.4 times higher, than ...
Ozolina, N. V., Nesterkina, I. S., Sitneva, L. A., Lapteva, T. I., Nurminsky, V. N., Kolesnikova, E. V., Salyaev, R. K.   +6 more
doaj  

Ricin B chain targeted to the endoplasmic reticulum of tobacco protoplasts is degraded by a CDC48- and vacuole-independent mechanism [PDF]

, 2008
The B chain of ricin was expressed and delivered to the endoplasmic reticulum of tobacco protoplasts where it disappeared with time in a manner consistent with degradation. This turnover did not occur in the vacuoles or upon secretion.
Asher, Bakker, Barlowe, Barlowe, Benatti, Blanchard, Brandizzi, Brauer, Braun, Carter, Contento, d'Enfert, d'Enfert, de Virgilio, Di Cola, Di Cola, Donoso, Ellgaard, Endo, Feiler, Fenteany, Ferrini, Frigerio, Frigerio, Frigerio, Frigerio, Frigerio, Gillespie, Glas, Hellens, Hong, Jarosch, Jolliffe, Jolliffe, Katiyar, Kisselev, Kong, Lord, Lord, Loureiro, Ma, Maliga, Marshall, Meng, Meusser, Muller, Nebenfuhr, Nuttall, Nuttall, Parodi, Pedrazzini, Phillipson, Pimpl, Rancour, Reichel, Roberts, Romisch, Saint-Jore-Dupas, Schmitz, Schmitz, Sheng, Smith, Speranza, Tabe, Taiz, Tamura, Tolchinsky, Tormakangas, Tsai, Vitale, Wales, Ye, Ye, Yuk   +73 more
core   +2 more sources

SIRT3‐Mediated Deacetylation of DRP1K711 Prevents Mitochondrial Dysfunction in Parkinson's Disease

Advanced Science, EarlyView.
SIRT3‐mediated deacetylation of DRP1 at K711 resists mitochondrial dysfunction and DA neuronal death in PD, uncovering a treatment target. Abstract Dysregulation of mitochondrial dynamics is a key contributor to the pathogenesis of Parkinson's disease (PD).
Ye Xi, Kai Tao, Xiaomin Wen, Dayun Feng, Zifan Mai, Hui Ding, Honghui Mao, Mingming Wang, Qian Yang, Jie Xiang, Jie Zhang, Shengxi Wu   +11 more
wiley   +1 more source

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

Vacuoles in mammals

BioArchitecture, 2013
A vacuole is a membrane-bound subcellular structure involved in intracellular digestion. Instead of the large “vacuolar” organelles that are found in plants and fungi, animal cells possess lysosomes that are smaller in size and are enriched with ...
Y. Wada
semanticscholar   +1 more source

The c-terminal extension of a hybrid immunoglobulin A/G heavy chain is responsible for its Golgi-mediated sorting to the vacuole [PDF]

, 2003
We have assessed the ability of the plant secretory pathway to handle the expression of complex heterologous proteins by investigating the fate of a hybrid immunoglobulin A/G in tobacco cells.
Denecke, J. (Jurgen), Frigerio, Lorenzo, Hadlington, Jane L., Ma, Julian K.-C., Nuttall, James, Santoro, Aniello, Vitale, A. (Alessandro)   +6 more
core   +2 more sources

Paclitaxel/Luteolin Coloaded Dual‐Functional Liposomes for Esophageal Cancer Therapy

Advanced Science, EarlyView.
The authors develop a pH‐sensitive aptamer‐modified liposome (EA2‐PSL‐PTX/LUT) to illustrate a strategy for the precise delivery of combinational chemotherapeutic drugs for esophageal squamous cell carcinoma (ESCC) targeted therapy. EA2‐PSL‐PTX/LUT provides efficient co‐loading, tumor targeting, and controlled release of luteolin and paclitaxel ...
Congyong Sun, Fei Xie, Huiyun Zhang, Lulu Feng, Yuting Wang, Chaofan Huang, Zhizhen Cui, Chao Luo, Li Zhang, Qilong Wang   +9 more
wiley   +1 more source

Mutation update for the ACTN2 gene

Human Mutation, Volume 43, Issue 12, Page 1745-1756, December 2022., 2022
Abstract ACTN2 encodes alpha‐actinin‐2, a protein expressed in human cardiac and skeletal muscle. The protein, located in the sarcomere Z‐disk, functions as a link between the anti‐parallel actin filaments. This important structural protein also binds N‐terminal titins, and thus contributes to sarcomere stability.
Johanna Ranta‐aho, Montse Olive, Marie Vandroux, Giorgia Roticiani, Cristina Dominguez, Mridul Johari, Annalaura Torella, Johann Böhm, Janina Turon, Vincenzo Nigro, Peter Hackman, Jocelyn Laporte, Bjarne Udd, Marco Savarese   +13 more
wiley   +1 more source

Rimmed vacuoles in Becker muscular dystrophy have similar features with inclusion myopathies.

PLoS ONE, 2012
Rimmed vacuoles in myofibers are thought to be due to the accumulation of autophagic vacuoles, and can be characteristic in certain myopathies with protein inclusions in myofibers.
Kazunari Momma, Satoru Noguchi, May Christine V Malicdan, Yukiko K Hayashi, Narihiro Minami, Keiko Kamakura, Ikuya Nonaka, Ichizo Nishino   +7 more
doaj   +1 more source