Results 221 to 230 of about 100,485 (295)

Oral mucosal manifestations with identical mutations to the bone marrow in a patient with VEXAS syndrome

open access: yes
Rheumatology &Autoimmunity, EarlyView.
Lilian Vasaitis   +5 more
wiley   +1 more source

Preservation of Autophagy May Be a Mechanism Behind Healthy Aging

open access: yesAging Cell, EarlyView.
Using CD4+ T cells from pairs of young and old healthy human donors, we found that autophagy in the older donor cells did not decline with aging suggesting a compensatory enhanced autophagic efficiency of human CD4+ T cells with age, which may be an adaptive mechanism behind healthy aging.
Arsun Bektas   +6 more
wiley   +1 more source

Mapping VEXAS‐associated and rare UBA1 variants in the United Kingdom: Insights from patient cohorts and the general population

open access: yesBritish Journal of Haematology, EarlyView.
VEXAS syndrome is a late‐onset inflammatory disorder with rheumatological and haematological features. Epidemiological studies of VEXAS syndrome so far have been limited. Analysis of various UK cohorts estimates the incidence of VEXAS to be 1.51/100 000, or 171 new cases in the population of men over the age of 50 who are being investigated for myeloid
Ana Martinez Rodriguez   +15 more
wiley   +1 more source

3D imaging of neuronal inclusions and protein aggregates in human neurodegeneration by multiscale x‐ray phase‐contrast tomography

open access: yesBrain Pathology, EarlyView.
x‐ray phase‐contrast tomography enabled three‐dimensional, label‐free visualization and quantification of protein aggregates in neurodegenerative diseases with isotropic submicrometer resolution. The study revealed distinct electron density patterns in Lewy bodies, Hirano bodies, granulovacuolar degeneration, and amyloid plaques, highlighting their ...
Jonas Franz   +9 more
wiley   +1 more source

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