Results 31 to 40 of about 345,031 (282)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Estudo comparativo da impregnação a vácuo de maçã (var. fuji), pêra (var. d' água e d' anjou), e manga (var. tommy atkins) [PDF]

, 2007
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de AlimentosA impregnação a vácuo (IV) de produtos porosos consiste na troca do gás e/ou líquido aprisionado dentro do poro do ...
Merlin, Kamila Bertol
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Propriedades físico-químicas e de textura de abacaxi (var. Pérola) desidratado enriquecido com cálcio por impregnação a vácuo [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia de Alimentos, Florianópolis, 2014.O processo de impregnação a vácuo (IV) em alimentos porosos consiste na troca do gás e/ou ...
Lima, Marla Mateus de
core  

Optimization of Vacuum Impregnation with Aqueous Extract from Hibiscus sabdariffa Calyces in Apple Slices by Response Surface Methodology: Effect on Soluble Phenols, Flavonoids, Antioxidant Activity, and Physicochemical Parameters

Applied Sciences
Vacuum impregnation (VI) of natural extracts is often used as a pretreatment for fruit dehydration. Apple slices were subjected to VI [XVP: vacuum pressure (−0.4 to −0.2 mbar), XIT: impregnation time (2–10 min), and XRT: restoration time (1–3 min)] of ...
Luis Miguel Anaya-Esparza, Ernesto Rodríguez-Lafitte, Zuamí Villagrán, Edward F. Aurora-Vigo, José Martín Ruvalcaba-Gómez, Walter Bernardo Símpalo-López, Fernando Martínez-Esquivias, Cristhian Henry Sarango-Córdova   +7 more
doaj   +1 more source

Revealing the role of sealing treatment on the electrochemical corrosion properties of HVOF-sprayed WC–20Cr3C2–7Ni/MWCNTs coating

Journal of Materials Research and Technology, 2023
In this study, the WC–20Cr3C2–7Ni/MWCNTs coating was prepared by high-velocity oxy-fuel (HVOF) spraying. Coatings were sealed with two types of sealants (i.e., silicone resin and aluminum phosphate) using both conventional and vacuum impregnations ...
Jiyue Qin, Zheng Wei, Ziyu Wei, Kailin Wang, Sheng Hong   +4 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Desidratação e caracterização físico-química de maçãs impregnadas com lactato de cálcio [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Alimentos, Florianópolis, 2013.A impregnação a vácuo (IV) de alimentos porosos consiste na troca do gás e/ou líquido ...
Assis, Fernanda Rosa
core  

Surface Modification and Sugar Infusion of Freeze-Dried Hawthorn via Combined Vacuum-Ultrasound Treatment

Foods
Hawthorn (Crataegus pinnatifida Bunge) is a medicinal and edible fruit whose sour taste and dense surface structure limit its application in food industries. Conventional sugar impregnation has long processing times and uneven sugar distribution. However,
Fei Shi, Jiguang Liu, Anlun Sun, Yuchuan Wang, Bo Wang   +4 more
doaj   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source