Results 71 to 80 of about 2,362,904 (300)

Genetic dysbiosis: the role of microbial insults in chronic inflammatory diseases [PDF]

, 2014
Thousands of bacterial phylotypes colonise the human body and the host response to this bacterial challenge greatly influences our state of health or disease. The concept of infectogenomics highlights the importance of host genetic factors in determining
Syed Tariq Sadiq, Nibali, L, Luigi Nibali, Henderson, B, Sadiq, ST, Brian Henderson, Donos, N, Nikos Donos   +7 more
core   +2 more sources

NSUN2‐Mediated m5C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA

Advanced Science, EarlyView.
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu, Xinkui Liu, Xiaoyan Yu, Qiaoqiao Han, Feifei Shi, Weiwei Song, Lu Liu, Chu Chu, Chenyang Shen, Zhen Zhang, Xia Li   +10 more
wiley   +1 more source

Warding Off Recurrent Yeast and Bacterial Vaginal Infections: Lactoferrin and Lactobacilli

Microorganisms, 2020
Vaginal infections are the most prevalent women’s health problem. Incompetent diagnosis, inappropriate treatments, and antibiotic resistance are the main causes of the unsatisfactory results of conventional, antimicrobic treatment for these ...
Fabiana Superti, Francesco De Seta
doaj   +1 more source

Characteristics of vaginal delivery systems [PDF]

Arhiv za farmaciju, 2017
The lumen of vagina is the usual route for application of vaginal preparations with antimicrobial drug substances, however, good vascularisation and high permeability of the large surface of vaginal mucosa, as well as the circumvention of metabolic ...
Filipović Milica, Đekić Ljiljana
doaj   +1 more source

Are women who work in bars, guesthouses and similar facilities a suitable study population for vaginal microbicide trials in Africa? [PDF]

, 2010
BACKGROUND: A feasibility study was conducted to investigate whether an occupational at-risk cohort of women in Mwanza, Tanzania are a suitable study population for future phase III vaginal microbicide trials.
Suzanna C. Francis, Stella Kasindi, Watson-Jones Deborah, Shagi, Charles, Claire Cook, Francis, Suzanna C, Watson-Jones, Deborah, Tobias Chirwa, Cook, Claire, Richard J. Hayes, Suzanna C Francis, Microbicides Development Programme, Louise Knight, Vallely Andrew, Celia Barberousse, Hayes, Richard J, Deborah Watson-Jones, Francis Suzanna C., Knight, Louise, Ross, David, Ian R Hambleton, Changalucha John, Everett Dean, Everett, Dean, Hambleton Ian R., Vallely, Andrew, Charles Shagi, Cook Claire, Changalucha, John, Shagi Charles, Hambleton, Ian R, Chirwa, Tobias, John Changalucha, Barberousse Celia, Kasindi Stella, Knight Louise, Dean Everett, Richard J Hayes, null null, Kasindi, Stella, Barberousse, Celia, Ian R. Hambleton, Ross David, Chirwa Tobias, Andrew Vallely, David Ross, Hayes Richard J.   +46 more
core   +1 more source

Tumor Exposomics: A New Paradigm for Individualized Continuous Exposure Monitoring

Advanced Science, EarlyView.
Tumor exposomics integrates continuous monitoring of environmental exposures, endogenous biological responses, and behavioral factors within a unified temporal framework. By combining multimodal sensing technologies with AI‐enabled causal modeling, this emerging paradigm reconstructs exposure‐damage trajectories and supports individualized dynamic risk
Kaicheng Shen, Weiyi Wang, Yang Wang, Yiqiang Wu, Xiaohong Liu, Wei Zhang, Juanjuan Ou   +6 more
wiley   +1 more source

Phase Separation of SF3B1 Serves as a Critical Post‐Transcriptional Regulator During Early Mouse Embryogenesis

Advanced Science, EarlyView.
Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao, Ting‐Yu Han, Yan‐Li Cheng, Yi‐Dan Zhang, Yu‐Wei Zhang, JinJian Guo, ShaoJun Zhang, WenZe Huang, Jing Zhang, Pei‐Yu Liao, Ying Xin, ChuanChen Chu, Qing‐Yuan Sun, ZhiZhen Liu, Xiang‐Hong Ou, Jun Xie   +15 more
wiley   +1 more source

Modern concept about the vaginal biocenosis of adolescent girls and its changes

Acta Biomedica Scientifica
The main representative of the vaginal biocenosis of adolescent girls after menarche and during the reproductive period of life is obligate-anaerobic lactobacilli.
M. Yu. Akhmetova, V. V. Florensov, O. Ya. Leshchenko, O. E. Baryaeva, L. I. Kolesnikova   +4 more
doaj   +1 more source

CHD8‐Dependent Chromatin Licensing Sustains Trophoblast Stem Cell Transcriptional Programs

Advanced Science, EarlyView.
In this study, Huang et al., identify chromatin remodeler CHD8 as an essential factor in TSC maintenance and placental development. CHD8‐dependent chromatin accessibility supports the occupancy of key trophoblast TFs and is coupled to KMT2A‐associated H3K4me3 deposition at TSC stem and cell cycle genes, providing a permissive chromatin environment for ...
Yuanyuan Huang, Zhenhua Hu, Jiali Liao, Lijun Huang, Jinyu Liu, Chen Tu, Yuchen Li, Lulu Xie, Shilei Bi, Xiaobo Fang, Jingsi Chen, Lili Du, Wei Sun, Haibin Wang, Shuang Zhang, Dunjin Chen, Zhaowei Tu   +16 more
wiley   +1 more source

Cell Lineage Tracing Identifies Hormone-Regulated and Wnt-Responsive Vaginal Epithelial Stem Cells

Cell Reports, 2020
Summary: The intact vaginal epithelium is essential for women’s reproductive health and provides protection against HIV and sexually transmitted infections. How this epithelium maintains itself remains poorly understood.
Ayesha Ali, Shafiq M. Syed, M. Fairuz B. Jamaluddin, Yolanda Colino-Sanguino, David Gallego-Ortega, Pradeep S. Tanwar   +5 more
doaj   +1 more source