Results 201 to 210 of about 226,558 (238)

THE PHYSIOLOGIC EFFECTIVENESS OF PROGESTERONE VAGINAL SUPPOSITORIES

The Journal of Clinical Endocrinology & Metabolism, 1954
This communication provides evidence that progesterone administered in the form of vaginal suppositories (25-50 mg) is readily absorbable utilizable and of greater potency and clinical effectiveness than progesterone used sublingually. Amenorrheic women show a rise in basal temperature of 1/2-1 degree within 24-36 hours of treatment with progesterone ...
openaire   +2 more sources

Pharmakokinetik vaginal applizierten Progesterons

Archives of Gynecology and Obstetrics, 1991
Der Einsatz von Gestagenen als therapeutische Moglichkeit bei Abortneigung, vorzeitiger Wehentatigkeit sowie Dysmenorrhoe erfolgt uberwiegend in Form synthetischer Gestagene, da Progesteron bei oraler Zufuhr einen hohen first-pass-Effekt aufweist. Vorausgegangene in-vitro-Untersuchungen zeigten, das bei Erreichen einer ausreichend hohen extrazellularen
M. Neises, A. Wischnik, H. Weidinger, B. Zsolnai   +3 more
openaire   +1 more source

Investigation of Product Quality Between Extemporaneously Compounded Progesterone Vaginal Suppositories and an Approved Progesterone Vaginal Gel

Drug Development and Industrial Pharmacy, 2004
The purpose of this investigation was to compare quality parameters, including product appearance, content uniformity, pH, weight uniformity, microbial limit testing and preservative effectiveness testing on extemporaneously compounded progesterone vaginal suppositories obtained from 10 randomly chosen compounding pharmacies (90 suppositories each ...
Vorapann, Mahaguna, J Mario, McDermott, Feng, Zhang, Felipe, Ochoa   +3 more
openaire   +2 more sources

Plasma levels of progesterone after vaginal, rectal, or intramuscular administration of progesterone

American Journal of Obstetrics and Gynecology, 1971
Abstract Plasma levels of progesterone were determined after vaginal, rectal, or intramuscular administration of 10 to 100 mg. of progesterone to 35 female volunteers. Progesterone was assayed by a competitive protein-binding technique. The absorption was very rapid by all three routes of administration, usually resulting in peak plasma levels of ...
S J, Nillius, E D, Johansson
openaire   +2 more sources

Comparative bioavailability of orally and vaginally administered progesterone

Fertility and Sterility, 1991
To study the pharmacokinetics of progesterone (P) in healthy premenopausal female volunteers to compare the bioavailability of orally or vaginally administered hormone.Subjects were randomly allocated to receive either oral P or a vaginal pessary then crossed over to the alternate preparation 1 month later.The study was conducted in outpatient setting ...
T R, Norman, C A, Morse, L, Dennerstein
openaire   +2 more sources

THE INTERACTION OF OESTROGEN AND PROGESTERONE ON THE VAGINAL CYCLE OF THE EWE

Journal of Endocrinology, 1956
SUMMARY The vaginal smear pattern of the intact ewe experiencing normal oestrous cycles was compared with that of the spayed untreated ewe, and with the spayed ewe injected with a physiological dose-level of oestradiol benzoate (ODB) administered either alone or alternating with progesterone (Prog.) injected in a time-dose ...
N W, MOORE, T J, ROBINSON
openaire   +2 more sources

Efficacy and safety of vaginal estriol and progesterone in postmenopausal women with atrophic vaginitis

Menopause, 2009
The aim of this study was to assess the efficacy and safety of intravaginal estriol and progesterone on atrophic vaginitis in postmenopausal women.Under a physician-sponsored Investigational New Drug application, 19 healthy postmenopausal women with atrophic vaginitis received vaginal suppositories containing estriol (1 mg) and progesterone (30 mg ...
Janet A, Chollet, Gloria, Carter, Leslie A, Meyn, Fred, Mermelstein, Judith L, Balk   +4 more
openaire   +2 more sources

The effects of local progesterone on stilbestrol-associated vaginal adenosis

American Journal of Obstetrics and Gynecology, 1974
A study was undertaken to evaluate the efficacy of progesterone suppositories in the therapy of vaginal adenosis. Five patients, 17 to 21 years of age, with biopsy-proved adenosis whose mothers received stilbestrol during pregnancy were treated with 20 mg. progesterone suppositories twice daily. No alteration of the menstrual pattern was noted.
A L, Herbst, S J, Robboy, G J, Macdonald, E, Scully   +3 more
openaire   +2 more sources

Concerns about the review of vaginal progesterone and the vaginal first-pass effect

Climacteric, 2018
Dear Sir,I read with interest the review paper “Vaginal progesterone and the vaginal first-pass effect” by M. P. Warren, published in your Journal1.
openaire   +3 more sources

Vaginal progesterone prophylaxis for preterm birth

The Lancet, 2016
Dimitrios, Papoutsis, Angeliki, Antonakou   +1 more
openaire   +4 more sources