Results 31 to 40 of about 785,437 (225)

Silicone elastomer formulations for improved performance of a multipurpose vaginal ring releasing dapivirine and levonorgestrel

International Journal of Pharmaceutics: X, 2021
A dapivirine-releasing silicone elastomer vaginal ring for reducing women's risk of HIV acquisition has recently been approved. A next-generation multipurpose vaginal ring releasing dapivirine and levonorgestrel is currently in development, offering ...
Yahya H. Dallal Bashi, Diarmaid J. Murphy, Clare F. McCoy, Peter Boyd, Leeanne Brown, Matthew Kihara, François Martin, Nicole McMullen, Kyle Kleinbeck, Bindi Dangi, Patrick Spence, Bashir Hansraj, Brid Devlin, R. Karl Malcolm   +13 more
doaj   +1 more source

Tree-Ring Skeleton Plotting by Computer

, 1979
Skeleton plotting is an established manual technique for representing the relative narrowness of tree rings in a single radius. These plots can be used as a visual aid to crossdating.
Cropper, John Philip
core   +4 more sources

Safety, Acceptability and Adherence of Dapivirine Vaginal Ring in a Microbicide Clinical Trial Conducted in Multiple Countries in Sub-Saharan Africa.

PLoS ONE, 2016
BackgroundThis was the first microbicide trial conducted in Africa to evaluate an antiretroviral-containing vaginal ring as an HIV prevention technology for women.ObjectivesThe trial assessed and compared the safety, acceptability and adherence to ...
Annalene Nel, Linda-Gail Bekker, Elizabeth Bukusi, Elizabeth Hellstrӧm, Philip Kotze, Philip Kotze, Cheryl Louw, Francis Martinson, Gileard Masenga, Elizabeth Montgomery, Nelisiwe Ndaba, Ariane van der Straten, Neliëtte van Niekerk, Cynthia Woodsong   +13 more
doaj   +1 more source

Rationale and Safety Assessment of a Novel Intravaginal Drug-Delivery System with Sustained DL-Lactic Acid Release, Intended for Long-Term Protection of the Vaginal Microbiome. [PDF]

PLoS ONE, 2016
Bacterial vaginosis is a prevalent state of dysbiosis of the vaginal microbiota with wide-ranging impact on human reproductive health. Based on recent insights in community ecology of the vaginal microbiome, we hypothesize that sustained vaginal DL ...
Hans Verstraelen, Chris Vervaet, Jean-Paul Remon   +2 more
doaj   +1 more source

A randomised trial of a contraceptive vaginal ring in women at risk of HIV infection in Rwanda: Safety of intermittent and continuous use.

PLoS ONE, 2018
BackgroundContraceptive vaginal rings could play a role in expanding the contraceptive method mix and in preparing communities for the introduction of HIV prevention and multipurpose rings.MethodsWe conducted an open label single-centre randomised ...
Evelyne Kestelyn, Stephen Agaba, Jennifer Ilo Van Nuil, Mireille Uwineza, Marie Michelle Umulisa, Lambert Mwambarangwe, Jean Claude Ndagijimana, Irith De Baetselier, Jozefien Buyze, Thérèse Delvaux, Tania Crucitti, Vicky Jespers, Janneke H H M van de Wijgert, Ring Plus Study Group   +13 more
doaj   +1 more source

Vaginal Contraceptive Rings

Annals of Medicine, 1993
Steroids diffuse through polysiloxone at a constant rate, and steroids placed in the vagina rapidly pass through the vaginal epithelium into the circulation. Combining these principles led to the development of contraceptive vaginal rings (CVR) consisting of various progestins, with and without oestrogen, placed in flexible polysiloxone, doughnut ...
openaire   +2 more sources

Self-reported removal and expulsion of the dapivirine vaginal ring: qualitative reports from female ring users and their male partners in the Ring Study (IPM 027)

BMC Public Health
Background/aims The dapivirine vaginal ring is a self-administered, women-initiated, discreet, long-acting HIV-1 prevention option for women. It was found to be safe and effective in healthy HIV-negative women who adhered to product use instructions, and
Cecilia Milford, Hariska Ramlal, Rorisang Mofokeng, Letitia Rambally Greener, Annaléne Nel, Jennifer Smit, Mariëtte Malherbe   +6 more
doaj   +1 more source

Biomarkers and biometric measures of adherence to use of ARV‐based vaginal rings

Journal of the International AIDS Society, 2016
Introduction Poor adherence to product use has been observed in recent trials of antiretroviral (ARV)‐based oral and vaginal gel HIV prevention products, resulting in an inability to determine product efficacy.
Randy M Stalter, Thomas R Moench, Kathleen M MacQueen, Elizabeth E Tolley, Derek H Owen, for the Consortium for Ring Adherence   +5 more
doaj   +1 more source

Three-Dimensionally Printed Vaginal Rings: Perceptions of Women and Gynecologists in a Cross-Sectional Survey

Pharmaceutics, 2023
Three-dimensional printing technologies can be implemented for the fabrication of personalized vaginal rings (VRs) as an alternative approach to traditional manufacturing. Although several studies have demonstrated the potential of additive manufacturing,
Laura Andrade Junqueira, Francisco José Raposo, Geraldo Sérgio Farinazzo Vitral, Atabak Ghanizadeh Tabriz, Dennis Douroumis, Nádia Rezende Barbosa Raposo, Marcos Antônio Fernandes Brandão   +6 more
doaj   +1 more source

Progesterone Vaginal Ring for Luteal Support [PDF]

The Journal of Obstetrics and Gynecology of India, 2014
Progesterone supplementation is universally used and has been shown to be beneficial in supplementation of the luteal phase in IVF. There are multiple options and the most commonly used include intramuscular and vaginal progesterone. A progesterone vaginal ring is a novel system for luteal support with advantages of controlled release with less ...
Laurel, Stadtmauer, Kay, Waud
openaire   +2 more sources