Results 91 to 100 of about 43,844 (304)

In vivo toxic and lethal cardiorespiratory effects of a synthetic quaternary ammonium salt derivative of haloperidol in mice

open access: yesAnimal Models and Experimental Medicine, Volume 8, Issue 5, Page 842-853, May 2025.
Hematoxylin–eosin (H&E) stains of the heart, liver, lung, and kidney show acute toxicity. Abstract Background To investigate the toxicity of N‐n‐butyl haloperidol iodide (F2), a quaternary ammonium salt derivative of haloperidol, in mice for potential therapeutic purposes. Methods The acute median lethal dose (LD50) of F2 was determined using the Bliss
Jilin Liao   +6 more
wiley   +1 more source

Acute Effects of Vagotomy on Baroreflex Equilibrium Diagram in Rats with Chronic Heart Failure

open access: yesClinical Medicine Insights: Cardiology, 2016
The arterial baroreflex system can be divided into the neural arc, from pressure input to efferent sympathetic nerve activity (SNA), and the peripheral arc, from SNA to arterial pressure (AP).
Toru Kawada   +3 more
doaj   +1 more source

Vagotomy Blocks the Induction of Interleukin-1β (IL-1β) mRNA in the Brain of Rats in Response to Systemic IL-1β

open access: yesJournal of Neuroscience, 1998
There is considerable interest in the mechanisms by which systemic cytokines signal the CNS to elicit centrally controlled biological actions. This study determined the effects of intraperitoneal injections of interleukin-1β (IL-1β) on IL-1β mRNA and IL ...
M. K. Hansen   +3 more
semanticscholar   +1 more source

Gut Microbiota and Hepatocellular Carcinoma: Metabolic Products and Immunotherapy Modulation

open access: yesCancer Medicine, Volume 14, Issue 9, May 2025.
ABSTRACT Background The relationship between hepatocellular carcinoma (HCC) and gut microbiota has gained attention for its impact on HCC immunotherapy. Methods Key gut microbial metabolites, including bile acids, toll‐like receptor 4, short‐chain fatty acids, and bacterial toxins, contribute to HCC progression and influence immune responses through ...
Kunmin Xiao   +4 more
wiley   +1 more source

Vagal-α7nAChR signaling promotes lung stem cells regeneration via fibroblast growth factor 10 during lung injury repair

open access: yesStem Cell Research & Therapy, 2020
Background Proliferation and transdifferentiation of lung stem cells (LSCs) could promote lung injury repair. The distal airways of the lung are innervated by the vagus nerve.
Xiaoyan Chen   +8 more
doaj   +1 more source

Precise role of H pylori in duodenal ulceration [PDF]

open access: yes, 2006
The facts that H pylori infection is commoner in duodenal ulcer (DU) patients than in the normal population, and that eradication results in most cases being cured, have led to the belief that it causes DU. However, early cases of DU are less likely than
Hobsley, M, Holton, J, Tovey, FI
core   +1 more source

Diverse perspectives on respiratory chemoreceptor interactions: Resuscitating an expired debate

open access: yes
Experimental Physiology, EarlyView.
Nasimi A. Guluzade   +3 more
wiley   +1 more source

α‐Synuclein in Parkinson's Disease: From Bench to Bedside

open access: yesMedicinal Research Reviews, Volume 45, Issue 3, Page 909-946, May 2025.
ABSTRACT α‐Synuclein (α‐syn), a pathological hallmark of PD, is emerging as a bridging element at the crossroads between neuro/immune‐inflammatory responses and neurodegeneration in PD. Several evidence show that pathological α‐syn accumulates in neuronal and non‐neuronal cells (i.e., neurons, microglia, macrophages, skin cells, and intestinal cells ...
Gabriele Bellini   +8 more
wiley   +1 more source

Vection-induced gastric dysrhythmias and motion sickness [PDF]

open access: yes
Gastric electrical and mechanical activity during vection-induced motion sickness was investigated. The contractile events of the antrum and gastric myoelectric activity in healthy subjects exposed to vection were measured simultaneously. Symptomatic and
Koch, K. L., Stern, R. M.
core   +1 more source

Medical versus surgical treatment for refractory or recurrent peptic ulcer [PDF]

open access: yes, 2016
BACKGROUND: Refractory peptic ulcers are ulcers in the stomach or duodenum that do not heal after eight to 12 weeks of medical treatment or those that are associated with complications despite medical treatment. Recurrent peptic ulcers are peptic ulcers
Gurusamy, KS, Pallari, E
core   +1 more source

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