Results 111 to 120 of about 771,705 (359)

DSOK‐0011 Potentially Regulates Circadian Misalignment and Affects Gut Microbiota Composition in Activity‐Based Anorexia Model

open access: yesInternational Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a metabolic‐psychiatric disorder characterized by severe weight loss, hypercortisolemia, and hypothalamic–pituitary–adrenal (HPA) axis activation. In this study, we investigated the effect of inhibiting cortisol regeneration via the enzyme 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) on the ...
Hiroki Kawai   +15 more
wiley   +1 more source

Interventional therapies for chronic heart failure: An overview of recent developments

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1081-1094, April 2025.
Abstract Heart failure (HF), the final manifestation of most cardiovascular diseases, has become a major global health concern, affecting millions of individuals. Despite basic drug treatments, patients present with high morbidity and mortality rates. However, recent advancements in interventional therapy have shown promising results in improving the ...
Bingchen Guo   +7 more
wiley   +1 more source

Hepatoportal Leptin Sensors and Their Reflex Effects on Autonomic Outflow in the Rat

open access: yesJournal of Obesity, 2011
Afferent nerve signals were recorded from a peripheral cut end of the small nerve bundle of the hepatic branch of the vagus nerve in anesthetized rats. An injection of leptin (100 pg, 0.1 mL) into the portal vein facilitated the afferent activity.
Akira Niijima
doaj   +1 more source

Can the vagus nerve serve as biomarker for vata dosha activity?

open access: yesJournal of Ayurveda and Integrative Medicine, 2019
This ‘discussion paper’ raises ‘provocative questions’ to identify physiological systems underlying vata dosha and candidate biomarkers for vata activity.
Venil N. Sumantran, Pratibha P. Nair
doaj   +1 more source

Phenotype characterization of heart failure with preserved ejection fraction in medical device and surgical trials

open access: yesESC Heart Failure, EarlyView.
This systematic review identified 24 clinical trials of medical device and surgical interventions for HFpEF, with 16 demonstrating at least safety and feasibility, but little evidence of long‐term benefit. Phenotype‐based responses suggest that certain interventions may benefit specific HFpEF subgroups, yet most trials suffered from heterogeneous ...
Kurdo Araz   +5 more
wiley   +1 more source

Internal senses of the vagus nerve

open access: yesNeuron, 2022
S. Prescott, S. Liberles
semanticscholar   +1 more source

Radiofrequency thermocoagulation for the treatment of refractory focal status epilepticus

open access: yesEpileptic Disorders, EarlyView.
Abstract This case study reports the first documented use of stereoelectroencephalography (SEEG)‐guided radiofrequency thermocoagulation (RFTC) to treat refractory status epilepticus (RSE). A 33‐year‐old woman with drug‐resistant epilepsy and recurrent RSE underwent SEEG to define her epileptogenic zone.
Odile Feys   +5 more
wiley   +1 more source

Transcutaneous vagus nerve stimulation: a new strategy for Alzheimer’s disease intervention through the brain-gut-microbiota axis?

open access: yesFrontiers in Aging Neuroscience
Transcutaneous vagus nerve stimulation (tVNS) is an emerging non-invasive technique designed to stimulate branches of the vagus nerve distributed over the body surface.
Long Yan   +21 more
doaj   +1 more source

Electrical stimulation of the vagus nerve protects against cerebral ischemic injury through an anti-infammatory mechanism

open access: yesNeural Regeneration Research, 2015
Vagus nerve stimulation exerts protective effects against ischemic brain injury; however, the underlying mechanisms remain unclear. In this study, a rat model of focal cerebral ischemia was established using the occlusion method, and the right vagus ...
Yao-xian Xiang   +5 more
doaj   +1 more source

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