Pan-pathway based interaction profiling of FDA-approved nucleoside and nucleobase analogs with enzymes of the human nucleotide metabolism. [PDF]
PLoS ONE, 2012 To identify interactions a nucleoside analog library (NAL) consisting of 45 FDA-approved nucleoside analogs was screened against 23 enzymes of the human nucleotide metabolism using a thermal shift assay. The method was validated with deoxycytidine kinase;
Louise Egeblad +7 more
doaj +1 more source
Clinical course and therapeutic approach to varicella zoster virus infection in children with rheumatic autoimmune diseases under immunosuppression. [PDF]
, 2016 To analyze the clinical presentation and complications of varicella zoster virus (VZV) infection in children with rheumatic diseases treated with immunosuppressive medication such as biological disease-modifying antirheumatic drugs (bDMARDs) and/or ...
Aeschlimann, F. +9 more
core +2 more sources
Valacyclovir in the treatment of acute retinal necrosis [PDF]
, 2012 Background: To report the outcome of oral valacyclovir as the sole antiviral therapy for patients with acute retinal necrosis (ARN). Methods: This study reports a retrospective, interventional case series of nine consecutive patients with ten eyes ...
A Aizman +41 more
core +1 more source
Global Thrombosis Test - a possible monitoring system for the effects and safety of dabigatran [PDF]
, 2015 © Otsui et al. 2015BACKGROUND: Dabigatran is an alternative to warfarin (WF) for the thromboprophylaxis of stroke in patients with non-valvular atrial fibrillation (NVAF). The advantage of dabigatran over WF is that monitoring is not required; however, a
Gorog, Diana A +8 more
core +2 more sources
PLoS ONE, 2021 IntroductionCongenital CMV infection is the first worldwide cause of congenital viral infection but systematic screening of pregnant women and newborns for CMV is still debated in many countries.ObjectivesThis systematic review aims to provide the state ...
Claire Périllaud-Dubois +5 more
doaj +1 more source
Melatonin as an immunomodulator in combined therapy of herpesvirus skin diseases associated with HIV
Journal of V. N. Karazin Kharkiv National University: Series Medicine, 2021 Introduction. Highly active antiretroviral therapy is the current standard of care for patients with HIV/AIDS. Although antiretroviral therapy is etiotropic, quite effective in reducing viral load, recurrent opportunistic infections can lead to adverse ...
Diana Dorosh +5 more
doaj +1 more source
Corticosteroids for Bell's palsy (idiopathic facial paralysis) [PDF]
, 2016 Background: Inflammation and oedema of the facial nerve are implicated in causing Bell's palsy. Corticosteroids have a potent anti-inflammatory action that should minimise nerve damage.
Daly, Fergus +6 more
core +2 more sources
Congenital Cytomegalovirus Infection: Management Update [PDF]
, 2017 Purpose of review Until recently, management options in congenital cytomegalovirus (cCMV) infection have been either conservative or termination of pregnancy.
Jones, CE, Khalil, A, Ville, Y
core +1 more source
Patient safety and estimation of renal function in patients prescribed new oral anticoagulants for stroke prevention in atrial fibrillation [PDF]
, 2013 OBJECTIVE: In clinical trials of dabigatran and rivaroxaban for stroke prevention in atrial fibrillation (AF), drug eligibility and dosing were determined using the Cockcroft-Gault equation to estimate creatine clearance as a measure of renal function ...
Ashman, N +6 more
core +2 more sources
Taiwan Journal of OphthalmologyPURPOSE: To study the efficacy of long-term antiviral monotherapy on herpes zoster ophthalmicus (HZO) with eye involvement. MATERIALS AND METHODS: The patients with primary, recurrent, and chronic HZO with at least 1 year of follow-up were included in ...
Arash Maleki +3 more
doaj +1 more source