Results 31 to 40 of about 22,709 (233)

TTC21B: From Modifier to Causative Gene in Joubert Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Biallelic pathogenic variants in TTC21B, encoding the retrograde intraflagellar transport protein IFT139, are a known cause of renal and skeletal ciliopathies. Single heterozygous variants in this gene were found to be enriched in a cohort of patients with various ciliopathy phenotypes, including three individuals with Joubert syndrome (JS), a
Valentina Serpieri, Fulvio D'Abrusco, Anna Pichiecchio, Thouraya Ben Younes, Ichraf Kraoua, Enza Maria Valente   +5 more
wiley   +1 more source

The ABCD of COPD… For Patients

Acta Médica Portuguesa, 2018
Chronic obstructive pulmonary disease is a chronic condition that requires the engagement of our patients in lifestyle changes and pharmacological treatment.
Ana Cysneiros, Catarina Antunes, Fernanda Paula, Filipe Froes   +3 more
doaj   +1 more source

Origin, evolution and biogeographic dynamics of the European rabbit (Oryctolagus cuniculus) in Southwestern Europe

The Anatomical Record, EarlyView.
Abstract The Pleistocene is a key period for understanding the evolutionary history and palaeobiogeography of the European rabbit (Oryctolagus cuniculus). The species was first documented in southeastern Iberia at the beginning of the Middle Pleistocene and appears to have rapidly spread throughout Southwestern Europe, where it was found in numerous ...
Maxime Pelletier
wiley   +1 more source

Hybrid Sequential Meniscal Suture Technique

Arthroscopy Techniques, EarlyView.
Abstract Meniscal preservation is a priority in the treatment of knee injuries because of the fundamental role of the meniscus in load absorption, joint stability, and chondral protection. Several repair techniques have been described, including inside‐out, outside‐in, and all‐inside approaches.
Jose Leonardo Rocha de Faria, Igor Araujo Farias, Rafael Erthal de Paula, Sandra Tie Nishibe Minamoto, Diego Ariel, Yuri Di Cavalcanti Sampaio, Naasson Trindade Cavanellas, João Antonio Matheus Guimarães, Geraldo da Rocha Motta, José Paulo Gabbi Aramburú Filho, Camilo Partezani Helito, Phelippe Valente Maia   +11 more
wiley   +1 more source

Valentes Flecheiros

Epígrafe, 2020
O final do século XVII foi marcante para a história das capitanias do norte da América portuguesa. Isso porque nesse período foi vivenciada a expansão das fronteiras oeste adentro, região mais ou menos desconhecida onde habitavam vários grupos ameríndios de diferentes culturas.
openaire   +2 more sources

Extrapolation and pharmacokinetic protocol design optimization for ceftriaxone as an exemplar for the development of antibiotics for children

British Journal of Clinical Pharmacology, EarlyView.
Aim Ceftriaxone is a cephalosporin commonly used for the treatment of acute, severe infections; however, there are conflicting data on its disposition properties in children, making it a suitable case study for the evaluation of the appropriateness of extrapolation approaches based on exposure matching principles for paediatric patients and exploring ...
Daniel Valente Neves, Umberto Villani, Salvatore D'Agate, Sean Oosterholt, Ricardo de Carvalho Cavalli, Fabio Carmona, Vera Lucia Lanchote, Oscar Della Pasqua   +7 more
wiley   +1 more source

C2. Pneumonia adquirida na comunidade (PAC) – influência da terapêutica com macrólidos ou novas fluoroquinolonas na evolução e duração de internamento

Revista Portuguesa de Pneumologia, 2003
A necessidade de cobertura dos agentes atípicos na terapêutica inicial de doentes hospitalizados com PAC é um assunto controverso que pode ter relação com a variação regional na incidência destes agentes.
G. Salvado, A. Oliveira, G. Duarte, B. Mendes, A. Ambar, F. Dias   +5 more
doaj   +1 more source

Host Cell Protein Challenges in Antibody Processing: Insights Into Persistence and Mitigation Strategies

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Persistence of HCPs remains a major purification challenge in biopharmaceutical manufacturing with direct consequences for product quality, patient safety, and regulatory compliance. Over the last two decades, deeper insights into the mechanisms driving HCP persistence have clarified why certain proteins evade removal during purification ...
Younghoon Oh, Andrew Cooke, Harshal Soni, Susan Liu, Mamadou Bah, Brianna Bellis, Laura Smith, Michael Capaldi, Nicholas Levy, Erik Wilhelm, Kristopher Barnthouse   +10 more
wiley   +1 more source

Metástases ósseas

Revista Portuguesa de Pneumologia, 1998
RESUMO: Os autores elaboraram uma revisão teórica sobre metástases ósseas, fouado os seguintes aspectos: incidência e distribuçāo; mecanisnaos e patogénese; diagnóstico, tratamento, avaliação da resposta ao tratamento e prognóstico.REV PORT ...
Maria De Jesus Valente, Fernanda Paula, Agostinho Costa, Maria José Melo   +3 more
doaj   +1 more source

Land birds on atolls: diversity, origin, and function

Biological Reviews, EarlyView.
ABSTRACT Oceanic islands are global hotspots of avian biodiversity and endemism. Their isolation and distinct environmental conditions have uniquely shaped the evolutionary trajectories of island birds, while, in turn, land bird communities have become critical providers of ecological functions to island ecosystems.
Sebastian Steibl, Alex S. Wegmann, Nick D. Holmes, Caitlin E. Andrews, Gérard Rocamora, Simon Ducatez, James C. Russell   +6 more
wiley   +1 more source