Results 41 to 50 of about 1,712,491 (259)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Sequentially valid tests for forecast calibration [PDF]

open access: yes, 2022
Forecasting and forecast evaluation are inherently sequential tasks. Predictions are often issued on a regular basis, such as every hour, day, or month, and their quality is monitored continuously.
Henzi, Alexander   +2 more
core   +2 more sources

Uptake Grant - Valid Evaluations - Multi-Year Humanitarian Financing Thematic Evaluation

open access: yes, 2018
Between 2014 and 2018, Valid Evaluations conducted a thematic evaluation for DFID. The evaluation aimed to test whether the introduction of longer-term funding could help build resilience, and whether it provided better value for money.
Valid Evaluations (19347295)
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Investigating the effect of phenanthrene and anthracene on biochemical compounds and growth in Spirulina platensis algae (J. Leonard, 1960) Arthospira-sp [PDF]

open access: yesبوم‌شناسی آبزیان, 2023
Polyaromatic hydrocarbons (PAH) with a benzene ring are petroleum compounds and are known as the most important cause of environmental pollution. Phenanthrene and anthracene are PAHs found in the aquatic environment.
valid hooti, ramin manffar
doaj  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Polyaniline-coated single-walled carbon nanotubes: synthesis, characterization and impact on primary immune cells

open access: yes, 2010
Functionalized carbon nanotubes are increasingly exploited as innovative components for the development of advanced biomedical devices. In this study we report a novel synthetic route for the formation of single-walled carbon nanotube (SWCNT)–polyaniline
YITZCHAIK S.   +6 more
core   +1 more source

Using Multiple Mini-Interviews for Students’ Admissions in Pakistan: A Pilot Study

open access: yesAdvances in Medical Education and Practice, 2020
Sonia Ijaz Haider,1 Muhammad Furqan Bari,2 Shamaila Ijaz3 1Department of Education and Development, Aga Khan University, Karachi, Pakistan; 2Department of Pathology, Dow University of Health Sciences, Karachi, Pakistan; 3Lahore Institute for Special Care
Haider SI, Bari MF, Ijaz S
doaj  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Muslim Communities Learning About Second-hand Smoke in Bangladesh (MCLASS II): a combined evidence and theory-based plus partnership intervention development approach

open access: yesPilot and Feasibility Studies, 2022
Introduction Deaths from second-hand smoke (SHS) exposure are increasing, but there is not sufficient evidence to recommend a particular SHS intervention or intervention development approach.
Ian Kellar   +6 more
doaj   +1 more source

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