Results 131 to 140 of about 7,539,132 (320)

Validation of nonlinear PCA

, 2012
Linear principal component analysis (PCA) can be extended to a nonlinear PCA by using artificial neural networks. But the benefit of curved components requires a careful control of the model complexity.
A Herman, A Ilin, AN Gorban, B Chalmond, B Christiansen, B Efron, B Schölkopf, BW Lu, D DeMers, JB Tenenbaum, LK Saul, M Scholz, MA Kramer, Matthias Scholz, MR Hestenes, ND Lawrence, P Demartines, R Hecht-Nielsen, S Girard, S Harmeling, S Mika, ST Roweis, T Hastie, T Kohonen, WW Hsieh, WW Hsieh, WW Hsieh   +26 more
core   +1 more source

The accumulation of myeloid‐derived suppressor cells participates in abdominal infection‐induced tumor progression through the PD‐L1/PD‐1 axis

Molecular Oncology, EarlyView.
This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang, Ting Guo, Xiaofang Xing, Xijuan Liu, Xuejun Gan, Yingai Li, Yan Liu, Fei Shan, Zhouqiao Wu, Jiafu Ji, Ziyu Li   +10 more
wiley   +1 more source

A study of the validation of atmospheric CO2 from satellite hyper spectral remote sensing

Advances in Climate Change Research, 2014
Three total column dry-air mole fractions of CO2 (XCO2) products from satellite retrievals, namely SCIAMACHY, NIES-GOSAT, and ACOS-GOSAT, in the Northern Hemisphere were validated by ground data from the Total Carbon Column Observing Network (TCCON). The
Miao Zhang, Xing-Ying Zhang, Rui-Xia Liu, Lie-Qun Hu   +3 more
doaj   +1 more source

Obelia: Scaling DAG-Based Blockchains to Hundreds of Validators [PDF]

arXiv
Obelia improves upon structured DAG-based consensus protocols used in proof-of-stake systems, allowing them to effectively scale to accommodate hundreds of validators. Obelia implements a two-tier validator system. A core group of high-stake validators that propose blocks as in current protocols and a larger group of lower-stake auxiliary validators ...
arxiv  

The PTTG1/VASP axis promotes oral squamous cell carcinoma metastasis by modulating focal adhesion and actin filaments

Molecular Oncology, EarlyView.
VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park, Sang Shin Lee, Shihyun Kim, Yeonjun Lee, Gyeonwon Park, Jung Oh Kim, Jongho Choi   +6 more
wiley   +1 more source

Validation approaches for satellite-based PM2.5 estimation: Assessment and a new approach [PDF]

arXiv, 2018
Satellite-derived aerosol optical depth (AOD) has been increasingly employed for the estimation of ground-level PM2.5, which is often achieved by modeling the relationship between AOD and PM2.5. To evaluate the accuracy of PM2.5 estimation, the cross-validation (CV) technique has been widely used.
arxiv  

NanoCMSer: a consensus molecular subtype stratification tool for fresh‐frozen and paraffin‐embedded colorectal cancer samples

Molecular Oncology, EarlyView.
Consensus molecular subtypes (CMS1‐4) have been identified to study colorectal cancer heterogeneity and serve as potential biomarkers. In this study, we developed and evaluated NanoCMSer, a NanoString‐based classifier using 55 genes, optimized for FF and FFPE to facilitate the clinical evaluation of CMS subtyping.
Arezo Torang, Simone van de Weerd, Veerle Lammers, Sander van Hooff, Inge van den Berg, Saskia van den Bergh, Miriam Koopman, Jan N. IJzermans, Jeanine M. L. Roodhart, Jan Koster, Jan Paul Medema   +10 more
wiley   +1 more source

Artifact Validity in Design Science Research (DSR): A Comparative Analysis of Three Influential Frameworks [PDF]

arXiv
Although the methodology of Design Science Research (DSR) is playing an increasingly important role with the emergence of the "sciences of the artificial", the validity of the resulting artifacts is occasionally questioned. This paper compares three influential DSR frameworks to assess their support for artifact validity.
arxiv  

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

Molecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou, Aliki Ntzifa, Victoria Tserpeli, Ioanna Balgkouranidou, Alkistis Papatheodoridi, Evangelia Razis, Helena Linardou, Christos Papadimitriou, Amanda Psyrri, Flora Zagouri, Stylianos Kakolyris, Evi Lianidou   +11 more
wiley   +1 more source