Results 111 to 120 of about 3,926,210 (300)
Counteranion-mediated dynamic kinetic asymmetric fluorination to access sulfur-stereogenic center
Nature CommunicationsSulfonimidoyl fluorides serve as versatile click linkers and have demonstrated significant utility in the construction of S-stereogenic centers for drug discovery and organic synthesis.
Zhihuang Chen +4 more
doaj +1 more source
Journal of Mechanical Engineering and Sciences, 2019 The accuracy of the predicted dynamic behaviour of an assembled structure using the frequency based substructuring (FBS) method is often found to be diverged from the experimental counterparts.
W. I. I. Wan Iskandar Mirza +4 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
International Journal of Advanced Nuclear Reactor Design and TechnologyIn this paper the turbulent mixing models of several domestic autonomous PWR subchannel software under review by the national nuclear safety administration were evaluated and studied.
Bin Jia +5 more
doaj +1 more source
Validation and validity of verbal autopsy procedures [PDF]
Population Health Metrics, 2011 Commentary Methods for interpreting verbal autopsy (VA) that have been validated fall into two major categories: (1) physician-certified verbal autopsy (PCVA), the commonlyused method in which one or more physicians ascertain causes of death based on their clinical judgment; and (2) computerized coding of verbal autopsy (CCVA), in which causes of death
openaire +4 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Model-driven description and validation of composite learning content [PDF]
, 2010 Authoring of learning content for courseware systems is a complex activity requiring the combination of a range of design and validation techniques. We introduce the CAVIAr courseware models allowing for learning content description and validation. Model-
Pahl, Claus, Melia, Mark
core +2 more sources
CROSS-VALIDATION ADJUSTMENT FOR MODEL SELECTION WITH CORRELATED DATA
, 2021 In the context of general linear models, often techniques are used with an independence assumption. Unfortunately, this assumption often does not hold in real data.
Adeeb, Ebrahim
core
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source