Results 91 to 100 of about 3,926,210 (300)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
, 2020 The publication describes methods and tools for development an information system (IS) for acceptance of the non-formal and informal learning results on base of computer ontologies.
Strokan', О.V. +4 more
core
Validation approach for persons with acute confusion : A literature review [PDF]
, 2005 This paper explores the theoretical background of validation approach as one of the therapeutic emotion-oriented approaches for confused persons. Persons experiencing acute or chronic confusion need physiological interventions as well as psychosocial and
Watanuki, Shigeaki
core
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Putting formal specifications under the magnifying glass: Model-based testing for validation [PDF]
, 2009 A software development process is effectively an abstract form of model transformation, starting from an end-user model of requirements, through to a system model for which code can be automatically generated.
Mark Utting +12 more
core +1 more source
ercbk/nested-cross-validation-comparison: v1.0
, 2021 Experimenting with various implementations and methods of nested cross-validation in R and ...
Eric Book
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Competent validation for subsidiarity : we validate where we know
, 2016 Validation is one of the toughest problems academics face, i.e. finding out where the new knowledge works and where it does not. Decision makers also engage in validation all the time, as they need to decide about the knowledge they use for their ...
Dörfler, Viktor
core +3 more sources
History and development of validation with the ESP-r simulation program [PDF]
, 2008 It is well recognised that validation of dynamic building simulation programs is a long-term complex task. There have been many large national and international efforts that have led to a well-established validation methodology comprising analytical ...
Macdonald, Iain +2 more
core +2 more sources