Results 91 to 100 of about 6,124,959 (299)

Microbiome eco-evolution of cultivated and wild rice species across the genus Oryza and its importance in supporting rice growth

Microbiome
Background Crop wild relatives and their microbiomes are essential for sustainable crop production. However, the co-evolution of wild rice species and their microbiomes remains poorly understood. Herein, we investigated microbiome assembly across 17 wild
Fei Luo, Yicong Cai, Yujie Cui, Xiangyang He, Jiawang Xu, Wanqiu Tang, Xiaoqing Wang, Yaohui Cai, Hongwei Xie, Wei Chen, Wenzhuo Li, Xia Ding   +11 more
doaj   +1 more source

Alternative scheme for frequency response function measurement of experimental-analytical dynamic substructuring

Journal of Mechanical Engineering and Sciences, 2019
The accuracy of the predicted dynamic behaviour of an assembled structure using the frequency based substructuring (FBS) method is often found to be diverged from the experimental counterparts.
W. I. I. Wan Iskandar Mirza, M. N. Abdul Rani, M. A. Yunus, R. Omar, M. S. Mohd Zin   +4 more
doaj   +1 more source

A bias correction for the minimum error rate in cross-validation

, 2009
Tuning parameters in supervised learning problems are often estimated by cross-validation. The minimum value of the cross-validation error can be biased downward as an estimate of the test error at that same value of the tuning parameter.
Tibshirani, Robert, Tibshirani, Ryan J.
core   +3 more sources

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Integrative network analysis suggests prioritised drugs for atopic dermatitis

Journal of Translational Medicine
Background Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disease whose pathophysiology involves the interplay between genetic and environmental factors, ultimately leading to dysfunction of the epidermis.
Antonio Federico, Lena Möbus, Zeyad Al-Abdulraheem, Alisa Pavel, Vittorio Fortino, Giusy del Giudice, Harri Alenius, Nanna Fyhrquist, Dario Greco   +8 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Effects of turbulent heat diffusion and viscosity on the simulation of turbulent mixing in autonomous PWR subchannel analysis software

International Journal of Advanced Nuclear Reactor Design and Technology
In this paper the turbulent mixing models of several domestic autonomous PWR subchannel software under review by the national nuclear safety administration were evaluated and studied.
Bin Jia, Jie-Ru An, Guang-Yu Zhu, Xin-Li Gao, Xue-Dong Qiao, Xiao-Qiang He   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source