Results 81 to 90 of about 2,465,911 (264)

Validity and Validation

Abstract Validity underscores all aspects of testing, from conceptualizing the targeted construct to evaluating the consequences of test score interpretations and uses. Validation entails constructing and evaluating coherent arguments for and against test score interpretations and uses, as well as the resulting consequences.
Lane Suzanne, Marion Scott F.
openaire   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Microbiome eco-evolution of cultivated and wild rice species across the genus Oryza and its importance in supporting rice growth

Microbiome
Background Crop wild relatives and their microbiomes are essential for sustainable crop production. However, the co-evolution of wild rice species and their microbiomes remains poorly understood. Herein, we investigated microbiome assembly across 17 wild
Fei Luo, Yicong Cai, Yujie Cui, Xiangyang He, Jiawang Xu, Wanqiu Tang, Xiaoqing Wang, Yaohui Cai, Hongwei Xie, Wei Chen, Wenzhuo Li, Xia Ding   +11 more
doaj   +1 more source

Who Validates the Validators?

, 2022
Given a fip:Metadata-schema and a validator for it, such as a sh:Validator or a JSON Schema, how do you determine that the validator is…valid? That it speaks the desired fip:Knowledge-representation-language, that it knows all the terms in a desired fip:Structured-vocabulary and checks their usage against a desired fip:Semantic-model?
openaire   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

Effects of turbulent heat diffusion and viscosity on the simulation of turbulent mixing in autonomous PWR subchannel analysis software

International Journal of Advanced Nuclear Reactor Design and Technology
In this paper the turbulent mixing models of several domestic autonomous PWR subchannel software under review by the national nuclear safety administration were evaluated and studied.
Bin Jia, Jie-Ru An, Guang-Yu Zhu, Xin-Li Gao, Xue-Dong Qiao, Xiao-Qiang He   +5 more
doaj   +1 more source

Identification of damage based on frequency response function (FRF) data

MATEC Web of Conferences, 2017
Mechanical joints, particularly fasteners such as bolted joints have a complex non-linear behaviour. The non-linearity might emerge from the material, geometry or by the contacts in the joints.
Sulaiman M. S. A., Yunus M. A., Bahari A. R., Abdul Rani M. N.   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source