Results 101 to 110 of about 6,124,959 (299)
Identification of damage based on frequency response function (FRF) data
MATEC Web of Conferences, 2017 Mechanical joints, particularly fasteners such as bolted joints have a complex non-linear behaviour. The non-linearity might emerge from the material, geometry or by the contacts in the joints.
Sulaiman M. S. A. +3 more
doaj +1 more source
Estimating the Maximum Expected Value: An Analysis of (Nested) Cross Validation and the Maximum Sample Average [PDF]
, 2013 We investigate the accuracy of the two most common estimators for the maximum expected value of a general set of random variables: a generalization of the maximum sample average, and cross validation.
van Hasselt, Hado
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
A Network Toxicology Approach for Mechanistic Modelling of Nanomaterial Hazard and Adverse Outcomes
Advanced ScienceHazard assessment is the first step in evaluating the potential adverse effects of chemicals. Traditionally, toxicological assessment has focused on the exposure, overlooking the impact of the exposed system on the observed toxicity.
Giusy del Giudice +9 more
doaj +1 more source
An information architecture for courseware validation [PDF]
, 2007 A lack of pedagogy in courseware can lead to learner rejec- tion. It is therefore vital that pedagogy is a central concern of courseware construction.
Melia, Mark, Pahl, Claus
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Remote Sensing, 2014 FengYun-3 (FY-3) Visible Infrared Radiometer (VIRR), along with its predecessor, Multispectral Visible Infrared Scanning Radiometer (MVISR), onboard FY-1C&D have had continuous global observation more than 14 years.
Na Xu +4 more
doaj +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Adoption of mechanization alternatives in oil palm crops in the Colombian Orinoquía natural region☆
Oilseeds and fats, crops and lipidsThe Orinoquía Natural Region in Colombia, particularly the Cumaral and Bajo Upía subzone, serves as the country’s primary palm oil production area. However, it faces with labor shortages and a lack of current mechanization data. This study aims to assess
Zapata-Hernández Arley +4 more
doaj +1 more source