Results 21 to 30 of about 6,428,897 (326)

A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice

open access: yesAlzheimer’s Research & Therapy, 2023
Background Hyperphosphorylation and intraneuronal aggregation of the microtubule-associated protein tau is a major pathological hallmark of Alzheimer’s disease (AD) brain.
Susan Barendrecht   +20 more
doaj   +1 more source

Synthesis and structure–activity relationships of pyrazole-based inhibitors of meprin α and β

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2023
Targeting metalloproteinases has been in the focus of drug design for a long time. However, meprin α and β emerged as potential drug targets just recently and are linked to several diseases with different pathological background.
Kathrin Tan   +5 more
doaj   +1 more source

Human activity recognition making use of long short-term memory techniques [PDF]

open access: yes, 2019
The optimisation and validation of a classifiers performance when applied to real world problems is not always effectively shown. In much of the literature describing the application of artificial neural network architectures to Human Activity ...
Shenfield, Alex, Wainwright, Richard
core   +1 more source

What does validation of cases in electronic record databases mean? The potential contribution of free text [PDF]

open access: yes, 2011
Electronic health records are increasingly used for research. The definition of cases or endpoints often relies on the use of coded diagnostic data, using a pre-selected group of codes.
Cassell, Jackie A   +3 more
core   +3 more sources

Temporal evolution of generalization during learning in linear networks [PDF]

open access: yes, 1991
We study generalization in a simple framework of feedforward linear networks with n inputs and n outputs, trained from examples by gradient descent on the usual quadratic error function.
Baldi, Pierre, Chauvin, Yves
core   +1 more source

Image Navigation for FY-4A Lightning Mapping Imager

open access: yesIEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2021
Navigation of images from lightning mapping instruments in geostationary orbits is very important for data applications. However, few scientific peer-reviewed papers have been reported, except a few works in the prelaunch tests.
Jing Wang   +7 more
doaj   +1 more source

Validation of Voting Committees [PDF]

open access: yes, 1997
This article contains a method to bound the test errors of voting committees with members chosen from a pool of trained classifiers. There are so many prospective committees that validating them directly does not achieve useful error bounds.
Bax, Eric
core   +4 more sources

Modal testing and modelling the dynamic characteristics of a plate with bolted joints

open access: yesJournal of Mechanical Engineering and Sciences, 2021
Modelling the dynamic characteristics of the bolted joints in a complex assembled structure with a high accuracy is very challenging due to the assumptions and uncertainties in the input data of the FE model.
A.R. Bahari   +3 more
doaj   +1 more source

Open source R for applying machine learning to RPAS remote sensing images [PDF]

open access: yes, 2017
The increase in the number of remote sensing platforms, ranging from satellites to close-range Remotely Piloted Aircraft System (RPAS), is leading to a growing demand for new image processing and classification tools.
Masiero, Andrea   +2 more
core   +2 more sources

Model-driven transformation and validation of adaptive educational hypermedia using CAVIAr [PDF]

open access: yes, 2010
Authoring of Adaptive Educational Hypermedia is a complex activity requiring the combination of a range of design and validation techniques.We demonstrate how Adaptive Educational Hypermedia can be transformed into CAVIAr courseware validation models ...
Melia, Mark, Pahl, Claus
core   +2 more sources

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