Results 31 to 40 of about 2,465,911 (264)

A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice

Alzheimer’s Research & Therapy, 2023
Background Hyperphosphorylation and intraneuronal aggregation of the microtubule-associated protein tau is a major pathological hallmark of Alzheimer’s disease (AD) brain.
Susan Barendrecht, An Schreurs, Stefanie Geissler, Victor Sabanov, Victoria Ilse, Vera Rieckmann, Rico Eichentopf, Anja Künemund, Benjamin Hietel, Sebastian Wussow, Katrin Hoffmann, Kerstin Körber-Ferl, Ravi Pandey, Gregory W. Carter, Hans-Ulrich Demuth, Max Holzer, Steffen Roßner, Stephan Schilling, Christoph Preuss, Detlef Balschun, Holger Cynis   +20 more
doaj   +1 more source

Synthesis and structure–activity relationships of pyrazole-based inhibitors of meprin α and β

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Targeting metalloproteinases has been in the focus of drug design for a long time. However, meprin α and β emerged as potential drug targets just recently and are linked to several diseases with different pathological background.
Kathrin Tan, Christian Jäger, Stefanie Geissler, Dagmar Schlenzig, Mirko Buchholz, Daniel Ramsbeck   +5 more
doaj   +1 more source

Image Navigation for FY-4A Lightning Mapping Imager

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2021
Navigation of images from lightning mapping instruments in geostationary orbits is very important for data applications. However, few scientific peer-reviewed papers have been reported, except a few works in the prelaunch tests.
Jing Wang, Xiaochong Tong, Lei Yang, Jian Shang, Chengbao Liu, Shulong Bao, Zhiqing Zhang, Jun Yang   +7 more
doaj   +1 more source

Once Validated, Always Validated? [PDF]

The Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 2007
YOU need a brief measure, say, of stress, or social resources, or functional status. You find one that not only seems to address the conceptual issues about which you are concerned, but for which information on validity and reliability have also been published. Moreover, it has been used frequently, and its name is well recognized.
openaire   +2 more sources

Sustainable intensification of oil palm production through integration with other crops: a review☆

Oilseeds and fats, crops and lipids
Unsustainable monoculture systems practices, driven by global demand for agricultural commodities like palm oil, contribute to deforestation, biodiversity loss, and soil degradation, compromising livelihoods and environmental health. With increasing land
Munévar-Martínez Daniel Eduardo, Ruiz-Álvarez Elizabeth, Estupiñán-Villamil María Celina, Mosquera-Montoya Mauricio   +3 more
doaj   +1 more source

Numerical And Experimental Investigations of Nonlinearity Behaviour In A Slender Cantilever Beam

MATEC Web of Conferences, 2018
Nonlinear problem is always occur in slender structures that are usually characterized by large displacements and rotations but small strains. Linear design assumption could lead to premature failure if the structure behaves nonlinearly.
Bahari A. R., Yunus M. A., Abdul Rani M. N., Ayub M. A., Nalisa A.   +4 more
doaj   +1 more source

Metrological characterization of standards – plastic films, which are used for calibration of nano volume spectrophotometers [PDF]

EPJ Web of Conferences
UV-VIS spectrophotometers, including nano drop (volume) spectrophotometers, provide an answer to all challenges in scientific and industrial laboratories, whether for pharmaceutical, chemical or service laboratories, all the way to more complex ...
Zarubica Veljko, Kubičela Edvard, Zarkov Boban, Srećković Milesa   +3 more
doaj   +1 more source

Carcinomas and Carcinoid Tumors of the Lungs and Bronchi in Children and Adolescents: The EXPeRT Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary lung carcinomas and bronchial carcinoid tumors (BC) are very rare malignancies in childhood. While typical BC and mucoepidermoid carcinomas are mostly low‐grade, localized tumors with a more favorable prognosis than in adults, necessitating avoidance of overtreatment, adenocarcinomas of the lung are often diagnosed at advanced disease ...
Michael Abele, Calogero Virgone, Michaela Kuhlen, Sabine Irtan, Yves Reguerre, Malgorzata Krawczyk, Ewa Bien, Tal Ben‐Ami, Maja Cesen, Ricardo Lopez‐Almaraz, Andrea Ferrari, Gianni Bisogno, Dominik T. Schneider, Abbas Agaimy, Constantin Lapa, Hubert Ducou le Pointe, Rainer Claus, Catherine Daniel, Ines B. Brecht, Daniel Orbach   +19 more
wiley   +1 more source

Representation of bolted joints in a structure using finite element modelling and model updating

Journal of Mechanical Engineering and Sciences, 2020
Efficient and accurate finite element (FE) modelling of bolted joints is essential for increasing confidence in the investigation of structural vibrations.
R. Omar, M. N. Abdul Rani, M. A. Yunus
doaj   +1 more source

Meta‐QTL s and haplotypes for efficient zinc biofortification of rice

The Plant Genome, 2023
Biofortification of rice with improved grain zinc (Zn) content is the most sustainable and cost‐effective approach to address Zn malnutrition in Asia. Genomics‐assisted breeding using precise and consistent Zn quantitative trait loci (QTLs), genes, and ...
Gaurav Joshi, Yan Paing Soe, Alvin Palanog, Tapas Kumer Hore, Chau Thanh Nha, Mark Ian Calayugan, Mary Ann Inabangan‐Asilo, Amery Amparado, Indra Deo Pandey, Pompe C. Sta Cruz, Jose E. Hernandez, B. P. Mallikarjuna Swamy   +11 more
doaj   +1 more source