Results 51 to 60 of about 2,465,911 (264)

MUUMI: an R package for statistical and network-based meta-analysis for multi-omics data integration

BMC Bioinformatics
Background Disentangling physiopathological mechanisms of biological systems through high-level integration of omics data has become a standard procedure in life sciences.
Simo Inkala, Michele Fratello, Giusy del Giudice, Giorgia Migliaccio, Angela Serra, Dario Greco, Antonio Federico   +6 more
doaj   +1 more source

CRISPR-mediated promoter editing of a cis-regulatory element of OsNAS2 increases Zn uptake/translocation and plant yield in rice

Frontiers in Genome Editing
Developing nutritious rice with a higher yield is one approach to alleviating the problem of micronutrient deficiency in developing countries, especially human malnutrition involving zinc and iron (Fe) deficiency, and achieving better adoption.
Yvonne Ludwig, Conrado Dueñas, Erwin Arcillas, Reena Jesusa Macalalad-Cabral, Ajay Kohli, Russell Reinke, Inez H. Slamet-Loedin   +6 more
doaj   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Consistent Calibration of VIRR Reflective Solar Channels Onboard FY-3A, FY-3B, and FY-3C Using a Multisite Calibration Method

Remote Sensing, 2018
The FengYun-3 (FY-3) Visible Infrared Radiometer (VIRR), along with its predecessor, the Multispectral Visible Infrared Scanning Radiometer (MVISR), onboard the FY-1C and FY-1D, has collected continuous daily global observations for 18 years.
Ling Wang, Xiuqing Hu, Lin Chen, Lingli He   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Validation of matching

2016 International Joint Conference on Neural Networks (IJCNN), 2016
We introduce a technique to compute probably approximately correct (PAC) bounds on precision and recall for matching algorithms. The bounds require some verified matches, but those matches may be used to develop the algorithms. The bounds can be applied to network reconciliation or entity resolution algorithms, which identify nodes in different ...
Ya Le, Eric Bax, Nicola Barbieri, David García-Soriano, Jitesh Mehta, James Li   +5 more
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Endothelial sensitivity to pro-fibrotic signals links systemic exposure to pulmonary fibrosis

Cell Death and Disease
Pulmonary fibrosis (PF) is a life-threatening condition characterised by excessive extracellular matrix deposition and tissue scarring. While much of PF research has focused on alveolar epithelial cells and fibroblasts, endothelial cells have emerged as ...
Lena Möbus, Laura Ylä-Outinen, Luca Mannino, Giorgia Migliaccio, Karoliina Kosunen, Nicoletta D’Alessandro, Angela Serra, Dario Greco   +7 more
doaj   +1 more source

The close interaction between hypoxia-related proteins and metastasis in pancarcinomas

Scientific Reports, 2022
Many primary-tumor subregions exhibit low levels of molecular oxygen and restricted access to nutrients due to poor vascularization in the tissue, phenomenon known as hypoxia.
Andrés López-Cortés, Lavanya Prathap, Esteban Ortiz-Prado, Nikolaos C. Kyriakidis, Ángela León Cáceres, Isaac Armendáriz-Castillo, Antonella Vera-Guapi, Verónica Yumiceba, Katherine Simbaña-Rivera, Gabriela Echeverría-Garcés, Jennyfer M. García-Cárdenas, Andy Pérez-Villa, Patricia Guevara-Ramírez, Andrea Abad-Sojos, Jhommara Bautista, Lourdes Puig San Andrés, Nelson Varela, Santiago Guerrero   +17 more
doaj   +1 more source