Results 21 to 30 of about 2,498,425 (263)

Evidence for Enhanced Efficacy of Passive Immunotherapy against Beta-Amyloid in CD33-Negative 5xFAD Mice

Biomolecules, 2022
Passive immunotherapy is a very promising approach for the treatment of Alzheimer’s disease (AD). Among the different antibodies under development, those targeting post-translationally modified Aβ peptides might combine efficient reduction in beta ...
Kathrin Gnoth, Stefanie Geissler, Julia Feldhaus, Nadine Taudte, Victoria Ilse, Sebastian Zürner, Sebastian Greiser, Ulf-Dietrich Braumann, Jens-Ulrich Rahfeld, Holger Cynis, Stephan Schilling   +10 more
doaj   +1 more source

A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice

Alzheimer’s Research & Therapy, 2023
Background Hyperphosphorylation and intraneuronal aggregation of the microtubule-associated protein tau is a major pathological hallmark of Alzheimer’s disease (AD) brain.
Susan Barendrecht, An Schreurs, Stefanie Geissler, Victor Sabanov, Victoria Ilse, Vera Rieckmann, Rico Eichentopf, Anja Künemund, Benjamin Hietel, Sebastian Wussow, Katrin Hoffmann, Kerstin Körber-Ferl, Ravi Pandey, Gregory W. Carter, Hans-Ulrich Demuth, Max Holzer, Steffen Roßner, Stephan Schilling, Christoph Preuss, Detlef Balschun, Holger Cynis   +20 more
doaj   +1 more source

Synthesis and structure–activity relationships of pyrazole-based inhibitors of meprin α and β

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Targeting metalloproteinases has been in the focus of drug design for a long time. However, meprin α and β emerged as potential drug targets just recently and are linked to several diseases with different pathological background.
Kathrin Tan, Christian Jäger, Stefanie Geissler, Dagmar Schlenzig, Mirko Buchholz, Daniel Ramsbeck   +5 more
doaj   +1 more source

Once Validated, Always Validated? [PDF]

The Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 2007
YOU need a brief measure, say, of stress, or social resources, or functional status. You find one that not only seems to address the conceptual issues about which you are concerned, but for which information on validity and reliability have also been published. Moreover, it has been used frequently, and its name is well recognized.
openaire   +2 more sources

Image Navigation for FY-4A Lightning Mapping Imager

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2021
Navigation of images from lightning mapping instruments in geostationary orbits is very important for data applications. However, few scientific peer-reviewed papers have been reported, except a few works in the prelaunch tests.
Jing Wang, Xiaochong Tong, Lei Yang, Jian Shang, Chengbao Liu, Shulong Bao, Zhiqing Zhang, Jun Yang   +7 more
doaj   +1 more source

Sustainable intensification of oil palm production through integration with other crops: a review☆

Oilseeds and fats, crops and lipids
Unsustainable monoculture systems practices, driven by global demand for agricultural commodities like palm oil, contribute to deforestation, biodiversity loss, and soil degradation, compromising livelihoods and environmental health. With increasing land
Munévar-Martínez Daniel Eduardo, Ruiz-Álvarez Elizabeth, Estupiñán-Villamil María Celina, Mosquera-Montoya Mauricio   +3 more
doaj   +1 more source

Metrological characterization of standards – plastic films, which are used for calibration of nano volume spectrophotometers [PDF]

EPJ Web of Conferences
UV-VIS spectrophotometers, including nano drop (volume) spectrophotometers, provide an answer to all challenges in scientific and industrial laboratories, whether for pharmaceutical, chemical or service laboratories, all the way to more complex ...
Zarubica Veljko, Kubičela Edvard, Zarkov Boban, Srećković Milesa   +3 more
doaj   +1 more source

Health‐Related Social Needs in Children With Sickle Cell Disease Are Associated With Worse Health‐Related Quality of Life

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell disease (SCD) face multiple acute and chronic medical complications that may impact their quality of life as reported by patients themselves. Health‐related social needs (HRSNs), such as food and housing insecurity, are common in people with SCD, but the association between HRSNs and patient‐reported ...
Sarah J. Marks, Molly Sonenklar, Cerelia Donald, Cecelia Valrie, Wally Smith, India Sisler   +5 more
wiley   +1 more source

Numerical And Experimental Investigations of Nonlinearity Behaviour In A Slender Cantilever Beam

MATEC Web of Conferences, 2018
Nonlinear problem is always occur in slender structures that are usually characterized by large displacements and rotations but small strains. Linear design assumption could lead to premature failure if the structure behaves nonlinearly.
Bahari A. R., Yunus M. A., Abdul Rani M. N., Ayub M. A., Nalisa A.   +4 more
doaj   +1 more source

The Combined Effect of Obesity and Contraceptive Use on Pulmonary Embolism in Adolescent Females Residing in the United States

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Combined oral contraceptive (COC) use in obese adult women dramatically increases the relative risk of developing a pulmonary embolism (PE). The risk of a PE in obese adolescent females taking contraceptives is currently unknown. The purpose of this investigation was to determine the effect of body mass index (BMI) and contraceptive
John Puetz, Joanne Salas
wiley   +1 more source