Results 181 to 190 of about 1,361,904 (215)

Construction and Validation of a Nomogram for Diagnosis of Female Stress Urinary Incontinence Combined with Anatomic/Intrinsic Urethral Sphincter Deficiency. [PDF]

Int J Womens Health
Hu G, Zhou L, Su W, Tang G, Zhao D, Tang J.   +5 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Detecting stigmatizing language in clinical notes with large language models for addiction care. [PDF]

Npj Health Syst
Sethi R, Caskey J, Gao Y, Churpek MM, Miller TA, Mayampurath A, Salisbury-Afshar E, Afshar M, Dligach D.   +8 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Lightweight FMCW radar framework for human activity recognition under limited data conditions. [PDF]

Sci Rep
Fard AS, Mashhadigholamali M, Zolfaghari S, Abedi H, Chakraborty M, Borzì L, Daneshtalab M, Shaker G.   +7 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Finding the most promising indications for novel treatments in oncology. [PDF]

NPJ Precis Oncol
Eckhoff M, Klingelschmitt S, Van Ruijssevelt L, Grossmann S, Zichner T, Stümpges P, Roschewitz D, Mlecnik B, Merger M, Graen P, Kumar J, Devereson A, Wurzer S, Bleys J, Albrecht B, Hach D, Haslinger C.   +16 more
europepmc   +1 more source