Results 41 to 50 of about 1,361,904 (215)

Spanish validation endorsement of SDM-Q-9, a new approach

BMC Public Health, 2019
Background The Shared Decision Making (SDM) model allows the patient to be part of their own disease treatment and control. The translation to Spanish of a questionnaire that measures the patient perception of SDM will allow enlarging the range of its ...
Geovanny Efraín Alvarado-Villa, Jorge Daniel Moncayo-Rizzo, Jorge Andrés Gallardo-Rumbea   +2 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Requirement Validation for Embedded Systems in Automotive Industry Through Modeling

IEEE Access, 2020
Requirement validation contributes significantly toward the success of software projects. Validating requirements is also essential to ensure the correctness of embedded systems in the auto industry. The auto industry emphasizes a lot on the verification
Danish Iqbal, Assad Abbas, Mazhar Ali, Muhammad Usman Shahid Khan, Raheel Nawaz   +4 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Systems validation: application to statistical programs

BMC Medical Research Methodology, 2005
Background In 2003, the United States Food and Drug Administration (FDA) released a guidance document on the scope of "Part 11" enforcement. In this guidance document, the FDA indicates an expectation of a risk-based approach to determining which systems
Carter Rickey E
doaj   +1 more source

A Validation Approach Considering the Uneven Distribution of Ground Stations for Satellite-Based PM_2.5 Estimation

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2020
Satellite remote sensing has been increasingly employed for the estimation of ground-level atmospheric PM2.5. There have been several cross-validation (CV) approaches applied for the validation of satellite-based PM2.5 estimation models.
Tongwen Li, Huanfeng Shen, Chao Zeng, Qiangqiang Yuan   +3 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Developing and Validating a Questionnaire for Assessing School Organizational Health from an Islamic Perspective [PDF]

مسائل کاربردی تعلیم و تربیت اسلامی
Objective: This study aims to develop and validate a questionnaire for assessing the school organizational health from an Islamic perspective. Method: This study was conducted in two main stages employing a mixed-method approach.
Mohammad Hasan Pardakhtci, Mohammad Reza Asadi Younesi, Seyed Alireza Ghasemi   +2 more
doaj