Results 41 to 50 of about 1,458,255 (265)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Constructing and standardizing a positivism questionnaire through an Islamic- Iranian approach
پژوهش در دین و سلامت, 2019 For downloading the full-text of this article please click here. Background and Objective: Due to the importance of an Islamic-Iranian scale in the domain of positivism, the present paper aimed to develop an instrument for measuring the positivism based
Lida Sabagh kermani +1 more
doaj
An Efficient Data Partitioning to Improve Classification Performance While Keeping Parameters Interpretable. [PDF]
PLoS ONE, 2016 Supervised machine learning methods typically require splitting data into multiple chunks for training, validating, and finally testing classifiers. For finding the best parameters of a classifier, training and validation are usually carried out with ...
Kristjan Korjus +2 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
RNAV GNSS FLIGHT VALIDATION APPROACH PROCEDURES FOR EPKT RWY27 [PDF]
Scientific Journal of Silesian University of Technology. Series Transport, 2016 The purpose of this document is to present evidence of the work carried out as part of the flight validation activities of the RNAV approach involving the instrument flight procedures (IFPs), down to the localizer performance with vertical (LPV) minima,
Andrzej FELLNER +2 more
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
An approach to validation of a multidimensional tool
Journal of the College of Community Physicians, 2003 IntroductionShort Form Health Survey-36 (SF-36) is a multidimensional measure of general health which has been used extensively in research on many population groups.
N. S. Gunawardena +2 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source