Results 101 to 110 of about 48,587,327 (320)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Validation of the method for determination of related impurities in the active antiviral ingredient of enisamium iodide

Zaporožskij Medicinskij Žurnal, 2018
The aim of the work. To validate a method for the related impurities determination in the enisamium iodide active pharmaceutical ingredient (API) by means of high-performance liquid chromatography (HPLC).
O. V. Burmaka, S. M. Hureieva, V. M. Marhitych   +2 more
doaj   +1 more source

Validation of a Multivariate Serum Profile for Epithelial Ovarian Cancer Using a Prospective Multi-Site Collection [PDF]

, 2010
In previous studies we described the use of a retrospective collection of ovarian cancer and benign disease samples, in combination with a large set of multiplexed immunoassays and a multivariate pattern recognition algorithm, to develop an 11-biomarker ...
Beth Y. Karlan, Brian C. Mansfield, Brigitte E. Miller, Eva Chalas, Glenn E. Bigsby, Greg P. Bertenshaw, James F. Barter, James P. Mapes, James W. Orr, Jinghua Zhao, Katharine J. Bergstrom, Laurie L. Stephen, Lynda D. Roman, Michael E. McCollum, Partha Seshaiah, Paul A. DiSilvestro, Ping F. Yip, Robert W. Holloway, Ronald D. Alvarez, Suraj Amonkar, Tzong-Hao Chen   +20 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Validación de la escala ESTE para medir la soledad de la población adulta Validação da escala ESTE para medir a solidão da população adulta ESTE scale validation to measure loneliness in adult population

Investigación y Educación en Enfermería, 2010
Objetivo. Validar la escala de medición de la soledad ESTE en población adulta que asiste a los grupos de la tercera edad del municipio de Bello (Colombia). Metodología. Estudio descriptivo de corte transversal.
Jairo León Cardona Jiménez, María Mercedes Villamil Gallego, Eucaris Henao Villa, Ángela Quintero Echeverri   +3 more
doaj  

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

A validação brasileira do Questionnaire of Smoking Urges

Cadernos de Saúde Pública
Este estudo teve por objetivo validar a versão brasileira do Questionnaire of Smoking Urges(QSU). Teve delineamento experimental, sendo que seus participantes foram distribuídos, aleatoriamente, em grupos de zero, 30 e 60 minutos de abstinência do tabaco.
Renata Brasil Araujo, Margareth da Silva Oliveira, Maria Augusta Mansur   +2 more
doaj  

Validity of Canadian studies [PDF]

BMJ, 2004
EDITOR—My detailed response to the news report by White on the validity of my studies is available on bmj.com.1 2 The report contains several inaccuracies. The typographic error of writing SE instead of SD had already been acknowledged. We did not ask the subjects to remember and recount 50 digits.
openaire   +2 more sources