Results 121 to 130 of about 52,085,429 (356)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Pooled results from 5 validation studies of dietary self-report instruments using recovery biomarkers for potassium and sodium intake.

American Journal of Epidemiology, 2015
We pooled data from 5 large validation studies (1999-2009) of dietary self-report instruments that used recovery biomarkers as referents, to assess food frequency questionnaires (FFQs) and 24-hour recalls (24HRs).
L. Freedman, J. Commins, J. E. Moler, W. Willett, L. Tinker, A. Subar, D. Spiegelman, D. Rhodes, N. Potischman, M. Neuhouser, A. Moshfegh, V. Kipnis, L. Arab, R. Prentice   +13 more
semanticscholar   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

Validation of the Colombian version of the Karolinska sleepiness scale [PDF]

Sleep Science
Introduction: Currently, daytime sleepiness is a prevalent condition worldwide. Locally validated instruments for measuring sleepiness are required.
María Camila Laverde-López, Franklin Escobar-Córdoba, Javier Eslava-Schmalbach   +2 more
doaj   +1 more source

Reducing the Probability of False Positive Research Findings by Pre-Publication Validation - Experience with a Large Multiple Sclerosis Database

, 2007
*Objective* We have assessed the utility of a pre-publication validation policy in reducing the probability of publishing false positive research findings.
Moritz M. Heinz, Martin M. Daumer, Katja K. Ickstadt, Siegfried S. Schach, Ulrike U. Held, George G. Ebers   +5 more
core  

PENGEMBANGAN MODUL PEMBELAJARAN IPS DENGAN TEMA PENYIMPANGAN SOSIAL DI KALANGAN MASYAKARAT TANAH AIR SEBAGAI BAHAN AJAR SISWA SMP KELAS VIII

, 2021
This study aimed to : 1) develop a Social Studies learning module for the theme of“Social Deviations among Communities in the Country”, and 2) investigate theappropriateness of the module for the theme of “Social Deviations among Communities inthe ...
Safitri, Ardila Elfira
core  

Evaluation of clinical prediction models (part 2): how to undertake an external validation study

British medical journal
External validation studies are an important but often neglected part of prediction model research. In this article, the second in a series on model evaluation, Riley and colleagues explain what an external validation study entails and describe the key ...
R. Riley, Lucinda Archer, Kym I. E. Snell, J. Ensor, P. Dhiman, Glen P. Martin, L. Bonnett, Gary S. Collins   +7 more
semanticscholar   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Measurement Properties of the Smartphone-Based B-B Score in Current Shoulder Pathologies

Sensors, 2015
This study is aimed at the determination of the measurement properties of the shoulder function B-B Score measured with a smartphone. This score measures the symmetry between sides of a power-related metric for two selected movements, with 100 ...
Claude Pichonnaz, Cyntia Duc, Nigel Gleeson, Céline Ancey, Hervé Jaccard, Estelle Lécureux, Alain Farron, Brigitte M. Jolles, Kamiar Aminian   +8 more
doaj   +1 more source

GEANT4 Validation Studies at the ISIS Muon Facility

, 2010
GEANT4 provides an extensive set of alternative hadronic models. Simulations of the ISIS muon production using three such models applicable in the energy range of interest are presented in this paper and compared with the experimental ...
Bungau, Adriana, Lord, James, King, Philip, Cywinski, R., Bungau, Cristian   +4 more
core