Results 101 to 110 of about 52,085,429 (356)

Tradução e validação do The five part questionnaire for identifying hypermobility para a língua portuguesa do Brasil Translation into Brazilian Portuguese and validation of the five-part questionnaire for identifying hypermobility

Revista Brasileira de Reumatologia, 2011
INTRODUÇÃO: A hipermobilidade articular (HA) é uma condição clínica hereditária em que há aumento da elasticidade articular em movimentos passivos. Na população em geral, a frequência varia entre 10% e 20%, podendo ser estimada por métodos específicos ...
Daniela Aparecida de Moraes, Carlos Alberto Baptista, José Alexandre Souza Crippa, Paulo Louzada-Junior   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The assessment of depression in people with multiple sclerosis: a systematic review of psychometric validation studies

BMC Psychiatry, 2016
BackgroundThe prevalence of depression in people with multiple sclerosis (PwMS) is high; however, symptoms common to both conditions makes measurement difficult.
D. Hind, D. Kaklamanou, D. Beever, R. Webster, Ellen Lee, M. Barkham, C. Cooper   +6 more
semanticscholar   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Semantic and cultural equivalence of the Intergenerational Exchanges Attitude Scale (IEAS)

Revista Brasileira de Geriatria e Gerontologia
Introduction: Understanding the multidimensionality of attitudes originating from exchanges between different generations is fundamental for the establishment of intergenerational cooperation and the reduction of stereotypes and prejudices.
Roberta dos Santos Tarallo, Anita Liberalesso Neri, Meire Cachioni   +2 more
doaj   +1 more source

The validation of pesticide leaching models

, 1996
The validation of pesticide leaching models presents particular problems where the number of model predictions is far in excess of the observed data.
Portwood, A. M., Leeds-Harrison, P. B., Armstrong, A. C., Catt, J. A., Harris, G. L.   +4 more
core   +1 more source

A new framework to enhance the interpretation of external validation studies of clinical prediction models.

Journal of Clinical Epidemiology, 2015
OBJECTIVES It is widely acknowledged that the performance of diagnostic and prognostic prediction models should be assessed in external validation studies with independent data from "different but related" samples as compared with that of the development
T. Debray, Y. Vergouwe, H. Koffijberg, D. Nieboer, E. Steyerberg, K. Moons   +5 more
semanticscholar   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source