Results 141 to 150 of about 2,104,233 (265)

Systematic profiling of conditional degron tag technologies for target validation studies. [PDF]

Nat Commun, 2022
Bondeson DP, Mullin-Bernstein Z, Oliver S, Skipper TA, Atack TC, Bick N, Ching M, Guirguis AA, Kwon J, Langan C, Millson D, Paolella BR, Tran K, Wie SJ, Vazquez F, Tothova Z, Golub TR, Sellers WR, Ianari A.   +18 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

CONTEST: A generalization of ONEST to estimate sample size for predictive augmented intelligence method validation studies. [PDF]

J Pathol Inform
Olson BK, Rosenthal JH, Kappedal RD, Olson NH.   +3 more
europepmc   +1 more source

Measurement of person-centred consultation skills among healthcare practitioners: a systematic review of reviews of validation studies. [PDF]

BMC Med Educ, 2023
van Dongen A, Stewart D, Garry J, McCambridge J.   +3 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The clinical translation of plasma p-tau217 warrants higher urgency than additional efficacy validation studies. [PDF]

Alzheimers Dement
Cui X, Lu Z.
europepmc   +1 more source

Assessment of 24-hour physical behaviour in adults via wearables: a systematic review of validation studies under laboratory conditions. [PDF]

Int J Behav Nutr Phys Act, 2023
Giurgiu M, Ketelhut S, Kubica C, Nissen R, Doster AK, Thron M, Timm I, Giurgiu V, Nigg CR, Woll A, Ebner-Priemer UW, Bussmann JBJ.   +11 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Multi-omics and experimental validation studies reveal key biomarkers of cellular senescence in diabetic retinopathy. [PDF]

Diabetol Metab Syndr
Li J, Yang H, Lin Y, Fang Z.
europepmc   +1 more source

Technical and Diagnostic Issues in Whole Slide Imaging Published Validation Studies. [PDF]

Front Oncol, 2022
Rizzo PC, Girolami I, Marletta S, Pantanowitz L, Antonini P, Brunelli M, Santonicco N, Vacca P, Tumino N, Moretta L, Parwani A, Satturwar S, Eccher A, Munari E.   +13 more
europepmc   +1 more source