Results 151 to 160 of about 52,085,429 (356)

Evaluation and Application of Best Practice in Analytical Method Validation

The coherent body of research described in the existing published work is concerned with new assay method development and validation using novel systematic approaches for pharmaceutical and diagnostic compounds.
Shabir, Ghulam
core  

Longitudinal variable selection by cross-validation in the case of many covariates [PDF]

Longitudinal models are commonly used for studying data collected on individuals repeatedly through time. While there are now a variety of such models available (Marginal Models, Mixed Effects Models, etc.), far fewer options appear to exist for the ...
Eva Cantoni, Chris Field, Joanna Mills Flemming, Elvezio Ronchetti   +3 more
core  

Avalanche studies and model validation in Europe, SATSIE. Final report [PDF]

, 2006
European ...
Issler, Dieter
core  

Characteristics of Controls used for validation studies.

, 2016
Characteristics of Controls used for validation studies.
Chaim Putterman (157043), Jie Han (128758), Yujin Ye (157008), Quan-zhen Li (2577007), Jinchun Zhou (425820), Sandeep Singh (66811), Chun Xie (157000), Chandra Mohan (157054), Yajuan Li (402995), Huihua Ding (2577010), Xin Zhou (54275), Ramesh Saxena (157049), Tianfu Wu (156995)   +12 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Validation Of Cancer Diagnoses In Electronic Health Records: Results From The Information System For Research In Primary Care (SIDIAP) In Northeast Spain

Clinical Epidemiology, 2019
Martina Recalde,1,2,* Cyntia B Manzano-Salgado,1,2,* Yesika Díaz,1 Diana Puente,1,2 Maria Del Mar Garcia-Gil,1 Rafael Marcos-Gragera,3,4 Josefa Ribes-Puig,5,6 Jaume Galceran,7 Margarita Posso,8 Francesc Macià,8 Talita Duarte-Salles1 ...
Recalde M, Manzano-Salgado CB, Díaz Y, Puente D, Garcia-Gil MDM, Marcos-Gragera R, Ribes-Puig J, Galceran J, Posso M, Macià F, Duarte-Salles T   +10 more
doaj  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Empirical Validation of Agent Based Models: A Critical Survey [PDF]

This paper addresses the problem of finding the appropriate method for conducting empirical validation in agent-based (AB) models, which is often regarded as the Achilles’ heel of the AB approach to economic modelling. The paper has two objectives. First,
Alessio Moneta, Paul Windrum, Giorgio Fagiolo   +2 more
core  

Results of validation studies.

, 2017
a) Variance of stiffness measurements and b) Difference of stiffness for autonomous palpation and indentation based measurement, for silicone with nodules of 3 mm and 9 mm. Results from validation studies for separate lateral force modulations (Lat.) and
Prokar Dasgupta (127595), Thrishantha Nanayakkara (692548), Jelizaveta Konstantinova (3749743), Kaspar Althoefer (774121), Giuseppe Cotugno (3749746)   +4 more
core   +1 more source