A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
The clinical translation of plasma p-tau217 warrants higher urgency than additional efficacy validation studies. [PDF]
Cui X, Lu Z.
europepmc +1 more source
Mapping QTLs and gene validation studies for Mg2+ uptake and translocation using a MAGIC population in rice. [PDF]
Zhi S +6 more
europepmc +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Pilot-scale depuration demonstrates the suitability of non-pathogenic Vibrio parahaemolyticus as a surrogate for commercial-scale validation studies. [PDF]
Lunda SL +4 more
europepmc +1 more source
School-Age Child Routines: Adaptation and Validation Studies of the Portuguese Version of the Child Routines Questionnaire. [PDF]
Major SO +4 more
europepmc +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Objetivos. Evaluar las propiedades psicométricas y desarrollar una versión reducida de la nueva escala de ansiedad. Materiales y métodos. La nueva escala de ansiedad de 130 ítems (NEA-130) se aplicó a 254 pacientes psiquiátricos ambulatorios de un ...
Antonio Lozano-Vargas +1 more
doaj
Multi-omics and experimental validation studies reveal key biomarkers of cellular senescence in diabetic retinopathy. [PDF]
Li J, Yang H, Lin Y, Fang Z.
europepmc +1 more source

