Results 201 to 210 of about 48,587,327 (320)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Validation studies of the Perinatal Affective Assessment Scales for Fathers (PAPA) and Mothers (PAMA) in Chilean parents. [PDF]

open access: yesBMC Pregnancy Childbirth
Cortés FP   +6 more
europepmc   +1 more source

The impact of the lung EDRN-CVC on Phase 1, 2, & 3 biomarker validation studies. [PDF]

open access: yesCancer Biomark, 2022
Kammer MN   +10 more
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Validation studies of the FLASH-TV system to passively measure children's TV viewing. [PDF]

open access: yesSci Rep
Vadathya AK   +14 more
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

Imaging tau pathology in Alzheimer's disease with positron emission tomography: lessons learned from imaging-neuropathology validation studies. [PDF]

open access: yesMol Neurodegener, 2022
Moscoso A   +7 more
europepmc   +1 more source

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