We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
A systematic review of sham acupuncture validation studies. [PDF]
Lim SM, Go E.
europepmc +1 more source
Two Factors, Five Factors, or Both? External Validation Studies of Negative Symptom Dimensions in Schizophrenia. [PDF]
Ahmed AO +12 more
europepmc +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Magnetic resonance imaging to detect tumor hypoxia in brain malignant disease: A systematic review of validation studies. [PDF]
Bai Y +3 more
europepmc +1 more source
Types of analysis of validation studies in nursing: scoping review. [PDF]
Tavares Chiavone FB +5 more
europepmc +1 more source
The General Self-Efficacy Scale: Multicultural Validation Studies
A. Luszczynska, U. Scholz, R. Schwarzer
semanticscholar +1 more source
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Target Validation Studies of PS48, a PDK-1 Allosteric Agonist, for the Treatment of Alzheimer's Disease Phenotype in APP/PS1 Transgenic Mice. [PDF]
Querfurth HW +5 more
europepmc +1 more source
Assessing Bias and Limitations of Clinical Validation Studies of Molecular Diagnostic Tests for Indeterminate Thyroid Nodules: Systematic Review and Meta-Analysis. [PDF]
DiGennaro C +7 more
europepmc +1 more source

