Results 61 to 70 of about 4,269,345 (275)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Validade da hipertensão autorreferida associa-se inversamente com escolaridade em brasileiros Validity of self-reported hypertension is inversely associated with the level of education in Brazilian individuals

Arquivos Brasileiros de Cardiologia, 2012
FUNDAMENTO: A hipertensão autorreferida é um dado de interesse para saúde pública e acessível em estudos epidemiológicos, cuja validade deve ser verificada para o adequado emprego dessa informação.
Soraya Sant'Ana de Castro Selem, Michele Alessandra Castro, Chester Luiz Galvão César, Dirce Maria Lobo Marchioni, Regina Mara Fisberg   +4 more
doaj   +1 more source

Validation Studies and Proficiency Testing [PDF]

Journal of AOAC INTERNATIONAL, 2002
Abstract Genetically modified organisms (GMOs) entered the European food market in 1996. Current legislation demands the labeling of food products if they contain <1% GMO, as assessed for each ingredient of the product. To create confidence in the testing methods and to complement enforcement requirements, there is an urgent need ...
Elke, Ankilam, Petra, Heinze, Simon, Kay, Guy, Van den Eede, Bert, Popping   +4 more
openaire   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Development and Validation of a Culturally-Tailored Breast Cancer Health Education Programme for Arab Women

Sultan Qaboos University Medical Journal, 2017
Objectives: This study aimed to develop and validate a health education programme to encourage breast cancer awareness and early detection behaviours among Arab women. Methods: This study took place between December 2015 and March 2016.
Esra Alkhasawneh, Yahya Al-Farsi, Fayez Al-Simadi, Michael Leocadio   +3 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Uterine Fibroid Symptom - Quality of Life questionnaire translation and validation into Brazilian Portuguese [PDF]

Revista Brasileira de Ginecologia e Obstetrícia, 2016
Purpose To translate into Portuguese, culturally adapt and validate the Uterine Fibroid Symptom - Quality of Life (UFS-QoL) questionnaire for Brazilian women with uterine leiomyoma.
Rita Oliveira da Silva, Mariano Tamura Vieira Gomes, Rodrigo de Aquino Castro, Cláudio Emílio Bonduki, Manoel João Batista Castello Girão   +4 more
doaj   +1 more source

The other GMP: good manufacturing practice and its importance in the validation of constructed pharmaceutical facilities [PDF]

, 2005
The work reported is part of an ongoing PhD study prompted by the particular difficulties encountered when two very different quality cultures interact (in this case Pharmaceutical industry clients and Construction industry providers).
Edge, Jerry, Greenwood, David, Render, Neil   +2 more
core  

A study of pre-validation

, 2007
Given a predictor of outcome derived from a high-dimensional dataset, pre-validation is a useful technique for comparing it to competing predictors on the same dataset.
Höfling, Holger, Tibshirani, Robert
core   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source