Results 91 to 100 of about 54,092,065 (345)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Cultural Adaptation and Psychometric Properties of Long-term Conditions Questionnaire for Patients With Diabetes Mellitus [PDF]

Journal of Client-centered Nursing Care
Background: To evaluate the improved outcomes for individuals with long-term conditions (LTCs), health care providers need a valid and reliable tool for assessing patients with one or more LTCs.
Raziyeh Iloonkashkooli, Zahra Hadian Shirazi, Mitra Soltanian, Giti Setoodeh, Marziyeh Momennasab   +4 more
doaj  

Construct Validation Instrument of Online Shooping Model (Case Study : Electronic Ticket) [PDF]

, 2011
The study objective is to develop measurement tool for online shopping model. Considering model built using latent variables, research instrument deployed was questionnaire.
Renny, R. (Renny)
core  

Validation of Diabetes Mellitus Patient Behavior Questionnaire in Primary Health Care Service [PDF]

, 2019
This study aimed to develop and validation a questionnaire as measurement instrument for knowledge and adherence behavior of DM patients in primary health care. Cross sectional study design was conducted in diabetes mellitus patient.
Akrom, A. (Akrom), Dania, H. (Haafizah), S, O. M. (Okta), Saputri, G. Z. (Ginanjar)   +3 more
core   +3 more sources

Identifying diabetes cases from administrative data: a population-based validation study

BMC Health Services Research, 2018
BackgroundHealth care data allow for the study and surveillance of chronic diseases such as diabetes. The objective of this study was to identify and validate optimal algorithms for diabetes cases within health care administrative databases for different
L. Lipscombe, J. Hwee, Lauren Webster, B. Shah, G. Booth, K. Tu   +5 more
semanticscholar   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A reference solution of the flow over a circular cylinder at Re=40

, 2013
The classical problem of the flow over a circular cylinder at Reynolds number 40 is considered using an accurate pseudo-spectral code. A new set of boundary conditions is proposed to improve the representation of the infinite flow domain, especially in ...
Biau, Damien, Gautier, Rémi, Lamballais, Eric   +2 more
core   +4 more sources

An International Multispecialty Validation Study of the IgG4‐Related Disease Responder Index

Arthritis care & research, 2018
IgG4‐related disease (IgG4‐RD) can cause fibroinflammatory lesions in nearly any organ, leading to organ dysfunction and failure. The IgG4‐RD Responder Index (RI) was developed to help investigators assess the efficacy of treatment in a structured manner.
Z. Wallace, A. Khosroshahi, M. Carruthers, C. Perugino, Hyon K. Choi, C. Campochiaro, E. Culver, Frank B. Cortazar, E. Della-Torre, M. Ebbo, Ana D. Fernandes, L. Frulloni, P. Hart, O. Karadag, S. Kawa, M. Kawano, Myung-Hwan Kim, M. Lanzillotta, Shoko Matsui, K. Okazaki, J. Ryu, T. Saeki, N. Schleinitz, Paula Tanasa, H. Umehara, G. Webster, Wen Zhang, J. Stone   +27 more
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source