Results 81 to 90 of about 2,566,277 (265)

Evaluation and Application of Best Practice in Analytical Method Validation

The coherent body of research described in the existing published work is concerned with new assay method development and validation using novel systematic approaches for pharmaceutical and diagnostic compounds.
Shabir, Ghulam
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Verification and validation of knowledge-based systems with an example from site selection. [PDF]

In this paper, the verification and validation of Knowledge-Based Systems (KBS) using decision tables (DTs) is one of the central issues. It is illustrated using real-market data taken from industrial site selection problems.One of the main problems of ...
Vanthienen, Jan, Wets, G, Witlox, Frank
core  

A risk prediction model for the assessment and triage of women with hypertensive disorders of pregnancy in low-resourced settings: the miniPIERS (Pre-eclampsia Integrated Estimate of RiSk) multi-country prospective cohort study.

, 2014
BACKGROUND: Pre-eclampsia/eclampsia are leading causes of maternal mortality and morbidity, particularly in low- and middle- income countries (LMICs). We developed the miniPIERS risk prediction model to provide a simple, evidence-based tool to identify ...
Jennifer A Hutcheon, Haniff Farizah, Jing Li (10611), Haniff, F, Qu, Z, Steyn, DW, D Wilhelm Steyn, Grobman, WA, Hall, David R., Jennifer A. Hutcheon (368523), Annettee Nakimuli (512186), Zulfiqar A. Bhutta (121489), Mariana Widmer (232499), Bhutta Shereen Z., Shereen Z Bhutta, Bhutta, ZA, miniPIERS Study Working Group, Farizah Haniff (512184), Shereen Z. Bhutta (512181), Widmer, M, Bhutta, Shereen Z., Ansermino, J. Mark, Diane Sawchuck (512189), Sawchuck Diane, Steyn, D. Wilhelm, Groen, Henk, Hall, DR, von Dadelszen Peter, Payne, Beth A., Henk Groen, Steyn D. Wilhelm, Nakimuli, A, Widmer, Mariana, Rozina Sikandar, Biryabarema, Christine, von Dadelszen, Peter, D. Wilhelm Steyn (512190), Merialdi, M, Laura A. Magee (512185), Magee Laura A., Qu, Ziguang, Peter von Dadelszen, Zhou Jian, Dadelszen, Peter von, David R. Hall (106818), MiniPIERS Study Working Grp, Sass, Nelson [UNIFESP], Grobman, William A., Widmer Mariana, Hutcheon, Jennifer A., Sikandar Rozina, Bhutta, Zulfiqar A., Rozina Sikandar (512188), Beth A Payne, Biryabarema, C, Annettee Nakimuli, Nakimuli, Annettee, Bhutta Zulfiqar A., Ansermino, JM, Grobman William A., Sikandar, Rozina, Ziguang Qu, Payne Beth A., Zhou, Jian, Henk Groen (444146), Sikandar, R, Zulfiqar A Bhutta, Groen Henk, Jian Zhou (28020), Magee, Laura A., Jian Zhou, Sass Nelson, Groen, Henk; id_orcid, Merialdi Mario, Jing Li, Li Jing, Zhou, J, von Dadelszen, P, Mario Merialdi (164060), William A Grobman, Bhutta, Zulfiqar Ahmed, Sawchuck, Diane, Hutcheon Jennifer A., Mario Merialdi, Payne, BA, Sawchuck, D, Nelson Sass, ?, ?, Hutcheon, JA, Merialdi, Mario, Biryabarema Christine, Hall David R., Ziguang Qu (512187), Nakimuli Annettee, Li, J, J Mark Ansermino, Qu Ziguang, Christine Biryabarema (512182), J. Mark Ansermino (426355), Farizah Haniff, Mariana Widmer, Bhutta, SZ, Beth A. Payne (512180), Haniff, Farizah, David R Hall, Groen, H, Nelson Sass (346028), Ansermino J. Mark, Sultanali, Rozina Sikandar, Li, Jing, Christine Biryabarema, Diane Sawchuck, von Dadelszen, Peter; id_orcid, Sass, Nelson, Sass, N, Peter von Dadelszen (258508), Magee, LA, William A. Grobman (512183), Laura A Magee   +118 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Validation procedures in radiological diagnostic models. Neural network and logistic regression [PDF]

The objective of this paper is to compare the performance of two predictive radiological models, logistic regression (LR) and neural network (NN), with five different resampling methods.
Pedro Delicado, Luis Martí, Estanislao Arana   +2 more
core  

Customer value co-creation behavior : scale development and validation

, 2013
This investigation reports a series of four studies leading to the development and validation of a customer value co-creation behavior scale. The scale comprises two dimensions: customer participation behavior and customer citizenship behavior, with each
Yi, Youjae, Gong, Taeshik
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source