Results 61 to 70 of about 2,566,277 (265)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Added predictive value of high-throughput molecular data to clinical data, and its validation [PDF]

, 2010
Hundreds of ''molecular signatures'' have been proposed in the literature to predict patient outcome in clinical settings from high-dimensional data, many of which eventually failed to get validated. Validation of such molecular research findings is thus
Sauerbrei, Willi, Boulesteix, Anne-Laure
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Validation of version-4.61 methane and nitrous oxide observed by MIPAS [PDF]

, 2009
peer reviewedThe ENVISAT validation programme for the atmospheric instruments MIPAS, SCIAMACHY and GOMOS is based on a number of balloon-borne, aircraft, satellite and ground-based correlative measurements.
S. Payan, E. Mahieu, Te, Yao, Notholt, J., De Mazière, Martine, Mencaraglia, F., Glatthor, N., J. Kuttippurath, Bianchini, G., Glatthor, Norbert, G. Maucher, Butz, Andre, Pirre, M., Oelhaf, Hermann, Keim, Corneli, Payne, V., Camy-Peyret, Claude C., Kuellmann, H., Volk, M. C., N. Huret, Huret, N., Oelhaf, H., M. C. Volk, H. Oelhaf, D. Smale, Payan, Sébastien, C. Vigouroux, Engel, Andreas, Wood, Stephen, T. Blumenstock, Mencaraglia, Francesco, A. Engel, V. Velazco, Grunow, K., Wetzel, Gerald, P. Jeseck, Notholt, Justus, Butz, A., M. Pirre, Wetzel, G., Vigouroux, C., N. Jones, Raspollini, P., Mikuteit, Sabine, Huret, Nathalie, Velazco, Voltaire, Pirre, Michel, G. Wetzel, Y. Te, Kuttippurath, Jayanarayanan, Raspollini, Piera, Piccolo, Chiara, Blumenstock, T., De Maziere, M., Mahieu, E., Grunow, Katja, Redaelli, G., Duchatelet, P., Payne, Vivienne, C. Keim, Cortesi, Ugo, Engel, Anja, F. Mencaraglia, Cortesi, U., Maucher, G., Camy-Peyret, C., Te, Y., S. Wood, V. Payne, Mahieu, Emmanuel, C. Camy-Peyret, Smale, D., Kuttippurath, J., Mikuteit, S., Redaelli, Gianluca, S. Mikuteit, H. Kuellmann, P. Raspollini, C. CAMY PEYRET, Duchatelet, Pierre, Kuellmann, Harry, Bianchini, Giovanni, Maucher, Guido, M. De Mazière, Stiller, G., Wood, S., Smale, Dan, K. Grunow, Bracher, A., A. Bracher, Jones, N., Stiller, Gabriele, Velazco, V., Blumenstock, Thomas, U. Cortesi, A. Butz, G. Stiller, J. Notholt, Payan, S., Volk, C.-Michael, P. Duchatelet, Jones, Nicholas, Engel, A., G. Bianchini, Keim, C., Bracher, Astrid, PAYAN, S, G. Redaelli, Vigouroux, Corinne, Piccolo, C., N. Glatthor, C. Piccolo, Volk, C. M., Jeseck, Pascal, Jeseck, P.   +114 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Towards the validation of adaptive educational hypermedia using CAVIAr [PDF]

, 2008
Migrating from static courseware to Adaptive Educational Hypermedia presents significant risk to the course creator. In this paper we alleviate some of this risk by outlining how the CAVIAr courseware validation framework can be used to validate some ...
Mark Melia, Mark Melia (12620263), Claus Pahl, Claus Pahl (12588787), Pahl, Claus, Melia, Mark   +5 more
core   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Validity of Canadian studies [PDF]

BMJ, 2004
EDITOR—My detailed response to the news report by White on the validity of my studies is available on bmj.com.1 2 The report contains several inaccuracies. The typographic error of writing SE instead of SD had already been acknowledged. We did not ask the subjects to remember and recount 50 digits.
openaire   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source