Results 61 to 70 of about 35,203,919 (243)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Ohio Retirement Study Council comparative performance study
, 2000 Semiannual; -Apr. 17, 2002.; Description based on Jun. 20, 2000 issue; title from cover of PDF document (viewed Feb. 13, 2006).; Vol. for Oct. 10, 2001 - Apr.
Ohio Retirement Study Council
core
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Ohio Retirement Study Council comparative performance study, period ending Dec. 31, 2002
, 2002 Semiannual; Nov. 13, 2000-; Title from cover of PDF document (viewed Feb. 13, 2006).; Vol. for 2002-2003 prepared by Milliman USA; vol. for 2004- prepared by Evaluation Associates.; Some vol. also called quarters.; Chronological designation based on date
Ohio Retirement Study Council
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Ohio Retirement Study Council comparative performance study, period ending 6/30/2002
, 2002 Semiannual; Nov. 13, 2000-; Title from cover of PDF document (viewed Feb. 13, 2006).; Vol. for 2002-2003 prepared by Milliman USA; vol. for 2004- prepared by Evaluation Associates.; Some vol. also called quarters.; Chronological designation based on date
Ohio Retirement Study Council
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Statistical validation of simulation models: A case study [PDF]
Rigorous statistical validation requires that the responses of the model and the real system have the same expected values. However, the modeled and actual responses are not comparable if they are obtained under different scenarios (environmental ...
Kleijnen, J.P.C.
core
Toxins, 2019 T-2 and HT-2 toxins and their main modified forms (T-2 glucoside and HT-2 glucoside) may co-occur in cereals and cereal-based products. A fluorescence polarization immunoassay (FPIA) was developed for the simultaneous determination of T-2 toxin, HT-2 ...
Vincenzo Lippolis +10 more
doaj +1 more source