Results 51 to 60 of about 2,566,277 (265)

Model-driven transformation and validation of adaptive educational hypermedia using CAVIAr [PDF]

, 2010
Authoring of Adaptive Educational Hypermedia is a complex activity requiring the combination of a range of design and validation techniques.We demonstrate how Adaptive Educational Hypermedia can be transformed into CAVIAr courseware validation models ...
Melia,Mark, Pahl, Claus, Melia, Mark, Pahl,Claus   +3 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

ENVISAT tropical validation of cloud and ozone parameters by high-altitude aircraft. [PDF]

, 2007
The validation of cloud top and ozone vertical column, measured by SCIAMACHY, were carried out respectively by lidars and in-situ and remote-sensing ozone instruments on-board the high altitude Geophysica aircraft.
Kostadinov, I., Gulde, T., MacKenzie, A. Robert, Ebersoldt, A., Blom, C., Lengel, A., Piesch, C., Ravegnani, F., Balestri, S., Liu, G. Y., Keim, C., Azzolini, R., Stefanutti, Leopoldo, Martinez, A. A., Petritoli, A.   +14 more
core  

Validation of the HADRIAN system using an ATM evaluation case study

, 2010
The HADRIAN human modelling system is under development as part of the EPSRC funded AUNT-SUE project. The HADRIAN system aims to foster a 'design for all' ethos by allowing ergonomists and designers to see the effects of different kinds of disability on ...
Gyi, Diane E., S. Birnie (7153667), Sims, Ruth, Peter M. Davis (7149860), S. Birnie, S.J. Summerskill, Steve Summerskill (1258776), K. Case, Davis, Peter, Keith Case (1250121), Diane Gyi (1247568), Case, Keith, P. Davis, C. Rohan, C. Rohan (7153664), P.N. Day (7153661), Rohan, C., Birnie, S., D.E. Gyi, Marshall, Russell, R.E. Sims, Ruth Sims (7148747), R. Marshall, P.N. Day, Russell Marshall (1257729), Day, Philip N., Summerskill, Steve   +26 more
core   +1 more source

Grid workflow validation using ontology-based tacit knowledge: A case study for quantitative remote sensing applications [PDF]

, 2016
Workflow for remote sensing quantitative retrieval is the “bridge” between Grid services and Grid-enabled application of remote sensing quantitative retrieval.
Li, Chi, Liu, Longli, Hill, Richard, Guang, Jie, Liu, Jia, Xue, Yong, Dong, Jing, Hu, Yingcui, Hu, Yincui   +8 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

No unbiased Estimator of the Variance of K-Fold Cross-Validation [PDF]

In statistical machine learning, the standard measure of accuracy for models is the prediction error, i.e. the expected loss on future examples. When the data distribution is unknown, it cannot be computed but several resampling methods, such as K-fold ...
Yoshua Bengio, Yves Grandvalet
core