Results 111 to 120 of about 54,092,065 (345)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Caries Detection and Classification in Photographs Using an Artificial Intelligence-Based Model—An External Validation Study

Diagnostics
Objective: This ex vivo diagnostic study aimed to externally validate a freely accessible AI-based model for caries detection, classification, localisation and segmentation using an independent image dataset.
Elisabeth Frenkel, Julia Neumayr, Julia Schwarzmaier, Andreas Kessler, Nour Ammar, Falk Schwendicke, Jan Kühnisch, Helena Dujic   +7 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Validation of the Santa Clara Ethics Scale (SCES) in Nursing Students: The Role of Ethics as a Protector of Student Compassion

Nursing Reports
Background: Ethics is one of the essential concepts associated with professional nursing practice, and can play a part in the development of compassion. Although a number of instruments have been developed for the measurement of ethics, most are context ...
Gabriel Vidal-Blanco, Javier Sánchez-Ruiz, Laura Galiana, Antonia Pades, Noemí Sansó   +4 more
doaj   +1 more source

Validation of Korean Version of the Oxford Cognitive Screen (K-OCS), a Post Stroke-Specific Cognitive Screening Tool [PDF]

Annals of Rehabilitation Medicine
Objective To establish and evaluate the validity of the recently developed Korean version of the Oxford Cognitive Screen (K-OCS), this study verified its reliability, validity, and diagnostic accuracy.
Eunyoung Cho, Sungwon Choi, Nele Demeyere, Rina Kim, Ikhyun Lim, MinYoung Kim   +5 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Psychometric Properties of the Bermond–Vorst Alexithymia Questionnaire (BVAQ) in the General Population and a Clinical Population

Frontiers in Psychiatry, 2018
IntroductionThe Bermond–Vorst Alexithymia Questionnaire (BVAQ) has been validated in student samples and small clinical samples, but not in the general population; thus, representative general-population norms are lacking.AimWe examined the factor ...
Lars de Vroege, Lars de Vroege, Wilco H. M. Emons, Klaas Sijtsma, Christina M. van der Feltz-Cornelis, Christina M. van der Feltz-Cornelis   +5 more
doaj   +1 more source

The other GMP: good manufacturing practice and its importance in the validation of constructed pharmaceutical facilities [PDF]

, 2005
The work reported is part of an ongoing PhD study prompted by the particular difficulties encountered when two very different quality cultures interact (in this case Pharmaceutical industry clients and Construction industry providers).
Edge, Jerry, Greenwood, David, Render, Neil   +2 more
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Validity of Canadian studies [PDF]

BMJ, 2004
EDITOR—My detailed response to the news report by White on the validity of my studies is available on bmj.com.1 2 The report contains several inaccuracies. The typographic error of writing SE instead of SD had already been acknowledged. We did not ask the subjects to remember and recount 50 digits.
openaire   +2 more sources