Results 101 to 110 of about 4,681,406 (303)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Investigating plant awareness: Methodologies, challenges and possibilities

Plants, People, Planet
Societal Impact Statement Plants are crucial for sustaining life on Earth, and understanding human relationships to plants is key to ensuring that the role of plants is recognized in biology research.
Irma Brkovic, Dawn Sanders, Eva Nyberg
doaj   +1 more source

Temporal description logic for ontology-based data access [PDF]

, 2013
Our aim is to investigate ontology-based data access over temporal data with validity time and ontologies capable of temporal conceptual modelling. To this end, we design a temporal description logic, TQL, that extends the standard ontology language ...
Artale, A., Kontchakov, Roman, Wolter, F., Zakharyaschev, Michael   +3 more
core   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Validity of a Self-administered Food Frequency Questionnaire for Genomic and Omics Research Among Pregnant Women: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Journal of Epidemiology
Background: The Tohoku Medical Megabank Project has initiated the Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) including genomic and omics investigations and conducted a self-administered food frequency questionnaire with the ...
Keiko Murakami, Misako Nakadate, Taku Obara, Misato Aizawa, Ippei Takahashi, Mami Ishikuro, Aoi Noda, Hisashi Ohseto, Noriyuki Iwama, Masatoshi Saito, Ribeka Takachi, Shiori Sugawara, Yudai Yonezawa, Takahiro Yamashita, Shigenori Suzuki, Junko Ishihara, Masayuki Yamamoto, Shinichi Kuriyama   +17 more
doaj   +1 more source

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source

Measures of New Constructs or Old Ones? The Case of Organizational Commitment and Job Satisfaction [PDF]

, 1991
The construct validity of organizational commitment has recently been investigated in several studies. The authors of these studies have concluded that organizational commitment is a valid construct, sufficiently distinct from job satisfaction.
Gerhart, Barry A., Judge, Timothy A.
core   +1 more source

Validity of the Hadronic Freeze-Out Curve

, 2011
We analyze hadro-chemical freeze-out in central Pb+Pb collisions at CERN SPS energies, employing the hybrid version of UrQMD which models hadronization by the Cooper-Frye mechanism, and matches to a final hadron-resonance cascade. We fit the results both
F Becattini, Karsch F, M Bleicher, M Mitrovski, McLerran L, R Stock, Stock R, T Kollegger, T Schuster   +8 more
core   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung, E‐nae Cheong, Jungmin So, Heung‐Won Kang, Yangsean Choi, Eun‐Jae Lee, Hyunjin Kim, Young‐Min Lim   +7 more
wiley   +1 more source