Results 81 to 90 of about 1,168,868 (263)

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Strategies, practices, and challenges in enhancing quality assurance in qualitative biomedical research: A multi-method study protocol [PDF]

Journal of Research Development in Nursing and Midwifery
Background: The qualitative research paradigm is crucial for understanding complex human phenomena, making credibility essential for its findings. Challenges in applying quality assessment criteria and promoting responsible practices in biomedical ...
Hamidreza Khankeh, Mohammad Saatchi, Mahdieh Motie, Shima Shirozhan, Ulrich Dirnagl   +4 more
doaj  

The Youth Risk Index: psychometrics, predicting the initiation of early adolescent substance use, and the breadth of liability detected

Frontiers in Child and Adolescent Psychiatry
IntroductionOver the last two decades, drug use epidemics have occurred across the world, including in countries with well-funded services for treatment and recovery, underscoring the need to bolster primary prevention.
Ty A. Ridenour, Ty A. Ridenour, Ty A. Ridenour, Nisha O'Shea Gottfredson, Jason Williams, Daniel S. Shaw, Maureen D. Reynolds, Cheryl A. Roberts, Richard Spoth, David R. Garnica-Agudelo, Idil Baran, Aysenil Belger, Diana H. Fishbein   +12 more
doaj   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

Psychometric models of emerging adulthood: an evaluation in a Chilean university sample

Frontiers in Psychology
This study analyzed three models of the Inventory of the Dimensions of Emerging Adulthood (IDEA): the original by Reifman et al., the version based on Arnett’s proposals, and the abbreviated version by Crocetti et al.
Paula Boero, Italo Trizano-Hermosilla, Eugenia V. Vinet   +2 more
doaj   +1 more source

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source

Psychometric Assessment of the Persian Version of the Structured Multidisciplinary Work Evaluation Tool (SMET) Questionnaire among Nurses [PDF]

بهداشت و ایمنی کار
Introduction: Nurses play a crucial role in hospital settings, often undertaking demanding tasks that exceed their physical and cognitive capacities.
MasoumehAlsadat Mousavi kani, Zeinab Kazemi, Marzieh Izadi Laybidi, Ehsan Garosi, Jamileh Abolghasemi, Mohammad Sadegh Ghasemi   +5 more
doaj