Results 81 to 90 of about 4,681,406 (303)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Casimir effect for curved geometries: PFA validity limits

, 2006
We compute Casimir interaction energies for the sphere-plate and cylinder-plate configuration induced by scalar-field fluctuations with Dirichlet boundary conditions.
H. B. G. Casimir, Holger Gies, K. A. Milton, Klaus Klingmüller, R. L. Jaffe   +4 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Acute stress and fear scales during the COVID-19 pandemic: development and evaluation in a Costa Rican sample

Población y Salud en Mesoamérica
Objective: In the context of the pandemic due to SARS-CoV-2, concerns were raised about how to adequately assess its impact on the wellbeing of the population.
Ana María Jurado-Solórzano, Gloriana Rodríguez-Arauz, Vanessa Smith-Castro, Mariano Rosabal-Coto, Sebastián Saborío, Henriette Raventós-Vorst, Benjamín Reyes-Fernández   +6 more
doaj   +1 more source

Validation of functional assessment of chronic illness therapy - spiritual well-being scale (FACIT-Sp-12) in Serbian oncology patients [PDF]

Psihologija
The Functional Assessment of Chronic Illness Therapy – Spiritual Well-Being scale (FACIT-Sp-12) is a 12-item questionnaire designed to assess spiritual well-being in individuals diagnosed with cancer and other chronic illnesses.
Klikovac Tamara, Rajić Isidora, Lazić Milica   +2 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Photographic Assessment of Change in Trichotillomania: Psychometric Properties and Variables Influencing Interpretation [PDF]

, 2016
Although photographic assessment has been found to be reliable in assessing hair loss in Trichotillomania, the validity of this method is unclear, particularly for gauging progress in treatment.
Compton, Scott N., Franklin, Maddison R., Franklin, Martin E., Houghton, David C., Neal-Barnett, Angela M., Saunders, Stephen M., Twohig, Michael P., Woods, Douglas W.   +7 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Psychometric evaluation of the reliability and validity of the literacy of suicide scale among Chinese nurses

Frontiers in Psychology
ObjectiveThis study aimed to Sinicize the Literacy of Suicide Scale (LOSS) and to test the reliability and validity of the LOSS with Chinese nurses.MethodsAfter authorization was obtained from the original author, the LOSS was translated into Chinese and
Zheshu Xie, Juanjuan Lin, Ying Fan, Feirong Tan, Yumei Zhou, Xing Liu   +5 more
doaj   +1 more source