Results 71 to 80 of about 1,168,868 (263)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Reliability and validity of the Mentalization Questionnaire in a potentially depressed group of Chinese college students

Frontiers in Psychiatry
PurposeMentalization, as a core psychosocial function, not only encompasses emotional regulation but also involves the perception and comprehension of one’s own and others’ emotional states, constituting a crucial capacity for establishing adaptive ...
Xin Huang, Zemin Zhou, Guang Yang, Jiao Liu, Xuan Li, Xuemei Li   +5 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Turkish Adaptation of Mothers’ Cultural Beliefs About Weaning Scale: A Validity and Reliability Study

Lokman Hekim Dergisi
Objective: The aim of this study was to determine the validity and reliability of the ‘Cultural Beliefs about Weaning Scale’ among breastfeeding women in the Turkish population.Method: The data of the methodologically designed study were collected by ...
Aytül Hadımlı, Emine Serap Çağan, Sevil Güner, Aysun Ekşioğlu   +3 more
doaj   +1 more source

Validation and validity of verbal autopsy procedures [PDF]

Population Health Metrics, 2011
Commentary Methods for interpreting verbal autopsy (VA) that have been validated fall into two major categories: (1) physician-certified verbal autopsy (PCVA), the commonlyused method in which one or more physicians ascertain causes of death based on their clinical judgment; and (2) computerized coding of verbal autopsy (CCVA), in which causes of death
openaire   +4 more sources

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Investigating plant awareness: Methodologies, challenges and possibilities

Plants, People, Planet
Societal Impact Statement Plants are crucial for sustaining life on Earth, and understanding human relationships to plants is key to ensuring that the role of plants is recognized in biology research.
Irma Brkovic, Dawn Sanders, Eva Nyberg
doaj   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Validity of a Self-administered Food Frequency Questionnaire for Genomic and Omics Research Among Pregnant Women: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Journal of Epidemiology
Background: The Tohoku Medical Megabank Project has initiated the Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) including genomic and omics investigations and conducted a self-administered food frequency questionnaire with the ...
Keiko Murakami, Misako Nakadate, Taku Obara, Misato Aizawa, Ippei Takahashi, Mami Ishikuro, Aoi Noda, Hisashi Ohseto, Noriyuki Iwama, Masatoshi Saito, Ribeka Takachi, Shiori Sugawara, Yudai Yonezawa, Takahiro Yamashita, Shigenori Suzuki, Junko Ishihara, Masayuki Yamamoto, Shinichi Kuriyama   +17 more
doaj   +1 more source