Results 61 to 70 of about 2,124,694 (305)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Transcultural Ethnic Validity Model and Intracultural Competence [PDF]

, 2012
To be a psychosocially competent person, each of us has to have both an internal and an external perspective on our self and our culture, a transcultural ethnic validity perspective.
Forrest B. Tyler, Tyler, Forrest B.
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Validity-Guided Synthesis of Reactive Systems from Assume-Guarantee Contracts

, 2018
This dataset contains the code and instructions needed to replicate the experimental results presented in the TACAS 2018 paper "Validity-Guided Synthesis of Reactive Systems from Assume-Guarantee Contracts".The problem of program synthesis - the ...
John Backes (4746375), Michael W. Whalen (4866703), Grigory Fedyukovich (4746372), Huajun Guo (4505905), Arie Gurfinkel (4866706), Andreas Katis (4866709), Andrew Gacek (4746369)   +6 more
core   +1 more source

A psychometric analysis of the Japanese version of the clinically useful depression outcome scale supplemented with questions for the DSM‐5 anxious distress specifier (CUDOS‐A)

Neuropsychopharmacology Reports
Aim The aim of the study was to identify the clinical significance of anxiety in those with depression, the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM‐5) defined criteria for an anxious distress specifier for major depressive ...
Yumi Aoki, Yoshikazu Takaesu, Yasuyuki Matsumoto, Hitoshi Sakurai, Takashi Tsuboi, Isa Okajima, Hisateru Tachimori, Yoko Komada, Koichiro Watanabe, Mark Zimmerman   +9 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Correlation between scores obtained by medical students in various educational courses and Basic Sciences and Pre-internship Comprehensive Exams

Development Strategies in Medical Education, 2016
Introduction: Predictive validity is one of important characteristics of a test; it means that what extent a test predicts scores of criterion test. This type of validity can be obtained through determining correlation between scores of two tests.
Akbar Pirzadeh, Shabnam Ahangar Davoodi, Bita Shahbazzadegan, Firooz Amani, Kazem Akharbin   +4 more
doaj  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Reliability and validity of two widely-used worry questionnaires: self-report and self-peer convergence [PDF]

, 1998
The reliability and validity of the Penn State Worry Questionnaire (PSWQ) and the Worry Domains Questionnaire (WDQ) were examined with self-ratings from a non-clinical sample of 148 students in a test-retest design across four weeks.
Stoeber, Joachim
core   +1 more source