Results 41 to 50 of about 1,168,868 (263)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Validation of matching

2016 International Joint Conference on Neural Networks (IJCNN), 2016
We introduce a technique to compute probably approximately correct (PAC) bounds on precision and recall for matching algorithms. The bounds require some verified matches, but those matches may be used to develop the algorithms. The bounds can be applied to network reconciliation or entity resolution algorithms, which identify nodes in different ...
Ya Le, Eric Bax, Nicola Barbieri, David García-Soriano, Jitesh Mehta, James Li   +5 more
openaire   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

A psychometric analysis of the Japanese version of the clinically useful depression outcome scale supplemented with questions for the DSM‐5 anxious distress specifier (CUDOS‐A)

Neuropsychopharmacology Reports
Aim The aim of the study was to identify the clinical significance of anxiety in those with depression, the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM‐5) defined criteria for an anxious distress specifier for major depressive ...
Yumi Aoki, Yoshikazu Takaesu, Yasuyuki Matsumoto, Hitoshi Sakurai, Takashi Tsuboi, Isa Okajima, Hisateru Tachimori, Yoko Komada, Koichiro Watanabe, Mark Zimmerman   +9 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Correlation between scores obtained by medical students in various educational courses and Basic Sciences and Pre-internship Comprehensive Exams

Development Strategies in Medical Education, 2016
Introduction: Predictive validity is one of important characteristics of a test; it means that what extent a test predicts scores of criterion test. This type of validity can be obtained through determining correlation between scores of two tests.
Akbar Pirzadeh, Shabnam Ahangar Davoodi, Bita Shahbazzadegan, Firooz Amani, Kazem Akharbin   +4 more
doaj  

On Legal Validity

, 2016
This paper presents a theoretical account of legal validity. We begin with a very simple criterial account of validity and discuss the possibility of elimination of such concept by means of procedure described in Ross' paper Tû-Tû. Then we discuss more ambitious theoretical proposals concerning validity, advocated by Grabowski and ...
Michal Araszkiewicz, Pompeu Casanovas
openaire   +4 more sources

Ecological Validity of Performance Validity Testing [PDF]

Archives of Clinical Neuropsychology, 2014
Performance validity tests (PVTs) have been shown to relate to neuropsychological performance, but no studies have looked at the ecological validity of these measures. Data from 131 veterans with a history of mild traumatic brain injury from a multicenter Veterans Administration consortium were examined to determine the relation between scores on a ...
Sara M, Lippa, Nicholas J, Pastorek, Jennifer, Romesser, John, Linck, Anita H, Sim, Nick M, Wisdom, Brian I, Miller   +6 more
openaire   +2 more sources

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source