Results 41 to 50 of about 1,218,638 (314)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Correlation between scores obtained by medical students in various educational courses and Basic Sciences and Pre-internship Comprehensive Exams

Development Strategies in Medical Education, 2016
Introduction: Predictive validity is one of important characteristics of a test; it means that what extent a test predicts scores of criterion test. This type of validity can be obtained through determining correlation between scores of two tests.
Akbar Pirzadeh, Shabnam Ahangar Davoodi, Bita Shahbazzadegan, Firooz Amani, Kazem Akharbin   +4 more
doaj  

Academic Hardiness Scale of College Students : Validity and Reliability Analysis Using Rasch Model

Jurnal Paedagogy
This study aims to analyze the validity and reliability of the academic hardiness scale that has been developed in the context of Indonesian culture. This research method used a survey with a quantitative approach to 50 students at the University of West
Fadhil Muhammad, Cece Rakhmat, Nandang Rusmana, Ipah Saripah, Aditia Kharisma Meliala   +4 more
doaj   +1 more source

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

Validity and Reliability of Seattle Angina Questionnaire Japanese Version in Patients With Coronary Artery Disease

Asian Nursing Research, 2010
The aim of this study was to evaluate the validity and reliability of the Seattle Angina Questionnaire, Japanese version (SAQ-J) as a disease-specific health outcome scale in patients with coronary artery disease.
Satomi Seki, RN, MSN, Naoko Kato, RN, MSN, Naomi Ito, RN, PhD, Koichiro Kinugawa, MD, PhD, Minoru Ono, MD, PhD, Noboru Motomura, MD, PhD, Atsushi Yao, MD, PhD, Masafumi Watanabe, MD, PhD, Yasushi Imai, MD, PhD, Norihiko Takeda, MD, PhD, Masashi Inoue, MD, PhD, Masaru Hatano, MD, PhD, Keiko Kazuma, RN, PhD   +12 more
doaj   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Who Validates the Validators?

, 2022
Given a fip:Metadata-schema and a validator for it, such as a sh:Validator or a JSON Schema, how do you determine that the validator is…valid? That it speaks the desired fip:Knowledge-representation-language, that it knows all the terms in a desired fip:Structured-vocabulary and checks their usage against a desired fip:Semantic-model?
openaire   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

The Development and Psychometric Assessment of Chinese Medication Literacy Scale for Hypertensive Patients (C-MLSHP)

Frontiers in Pharmacology, 2020
ObjectiveTo develop the medication literacy scale for patients with hypertension, and to test the reliability and validity of the scale.MethodsThe initial draft of the scale was formulated based on the operationalization of medication literacy with four ...
Zhuqing Zhong, Zhuqing Zhong, Shuangjiao Shi, Shuangjiao Shi, Yinglong Duan, Zhiying Shen, Feng Zheng, Siqing Ding, Siqing Ding, Aijing Luo   +9 more
doaj   +1 more source