Results 41 to 50 of about 577,511 (310)

Building validity evidence for the use of aggregate scores in accountability [PDF]

, 2021
High stakes test-based accountability systems primarily rely on aggregates and derivatives of scores from tests that were originally developed to measure individual student mastery of content specifications.
Hoeve, Karen Blackburn, NC DOCKS at The University of North Carolina at Greensboro   +1 more
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

DIAGNOSTIC VALIDITY OF SCREENING QUESTIONNAIRE AMERICAN COLLEGE OF SPORTS MEDICINE/AMERICAN HEART ASSOCIATION

Journal of Physical Education, 2019
The prevention of cardiovascular events is one of the main objectives of a preexercise screening questionnaire. The aim of this study was to evaluate the diagnostic validity of ACSM/AHA questionnaire (AAPQ), through the Sensitivity (Se), Specificity (Sp)
Geraldo de Albuquerque Maranhão Neto, Tony Meireles Santos, Rodrigo Cunha de Mello Pedreiro, Hugo Andrade do Carmo, Raiane Tavares Custódio Jardim, Andrea de Lorenzo   +5 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Reliability and validity of physical fitness field tests for adults aged 55 to 70 years

, 2005
The aim of this study was to examine the reliability and validity of field tests for assessing physical function in mid-aged and young-old people (55–70 y).
Brown, W., Armit, C., Brown, Wendy, Ritchie, Carrie, Trost, Stewart, Trost, S.G., Ritchie, C.   +6 more
core   +1 more source

The work role functioning questionnaire 2.0 (dutch version): examination of its reliability, validity and responsiveness in the general working population [PDF]

, 2013
Purpose: The promotion of a sustainable, healthy and productive working life attracts more and more attention. Recently the Work Role Functioning Questionnaire (WRFQ) has been cross-culturally translated and adapted to Dutch.
Bultmann, Ute; id_orcid, van der Klink, Jac J. L., van der Klink, J.J., Bultmann, U., Abma, F.I., Abma, Femke I., Bultmann, Ute   +6 more
core   +1 more source

Validity of G-36 and knowledge tests in relation to performance at a training program

Estudos de Psicologia (Campinas)
This study aimed to investigate the predictive validity of academic grades and G-36 scores in personnel selection. The sample was compose by 83 individuals from public organization with mean age of 22.01 (SD=2.99) years old, being 81.9% males and 91.6 ...
Alina Gomide Vasconcelos, Jáder dos Reis Sampaio, Elizabeth do Nascimento   +2 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Reliability, criterion-concurrent validity, and construct-discriminant validity of a head-marking version of the taekwondo anaerobic intermittent kick test

, 2021
This study aimed to examine the reliability and validity of a head-marking version of the taekwondo anaerobic intermittent kick test (TAIKT-head). Twenty-seven (21 males and 6 females) taekwondo athletes performed TAIKT-head on two occasions (test-retest)
Anis Chaouachi, Mohamed Arbi Mejri, Mourad Hambli, David G. Behm, Amel Tayech, Issam Makhlouf, Aaron Uthof   +6 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source