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Antitumor platinum(IV) derivatives of oxaliplatin with axial valproato ligands

Journal of Inorganic Biochemistry, 2014
We report new anticancer prodrugs, platinum(IV) derivatives of oxaliplatin conjugated with valproic acid (VPA), a well-known drug having histone deacetylase inhibitory activity. Like most platinum(IV) derivatives, the cytotoxicity of the conjugates was lower in cell culture than that of oxaliplatin, but greater than those of its Pt(IV) derivative ...
Vojtech, Novohradsky   +7 more
openaire   +2 more sources

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